|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:receptor_tyrosine_kinases
phosphorylation
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:discoveredBy
|
gptkb:Kazuo_Ui
|
|
gptkbp:discoveredIn
|
1985
|
|
gptkbp:domain
|
gptkb:PH_domain
gptkb:EF-hand_domain
C2 domain
SH2 domain
SH3 domain
X and Y catalytic domains
|
|
gptkbp:encodedBy
|
PLCG1 gene
|
|
gptkbp:enzymeCommissionNumber
|
3.1.4.11
|
|
gptkbp:fullName
|
Phospholipase C gamma 1
|
|
gptkbp:function
|
generates second messengers IP3 and DAG
hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2)
|
|
gptkbp:gene
|
gptkb:PLCG1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PLCγ1
|
|
gptkbp:interactsWith
|
gptkb:EGFR
gptkb:FGFR1
gptkb:PI3K
gptkb:Src_family_kinases
gptkb:Grb2
gptkb:Shc
|
|
gptkbp:involvedIn
|
cell differentiation
cell proliferation
signal transduction
angiogenesis
immune response
|
|
gptkbp:locatedOnChromosome
|
20q12-q13.1
|
|
gptkbp:location
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
~150 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
2PLC
|
|
gptkbp:phosphorylates
|
Tyr1254
Tyr771
Tyr775
Tyr783
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:significance
|
implicated in cancer
implicated in immune disorders
|
|
gptkbp:UniProtID
|
P19174
|
|
gptkbp:bfsParent
|
gptkb:PLCγ
gptkb:MET_gene
gptkb:LAT_(gene)
gptkb:LAT_(protein)
|
|
gptkbp:bfsLayer
|
7
|