|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:PDGFRB
gptkb:CD140b
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:dermatofibrosarcoma_protuberans
gptkb:infantile_myofibromatosis
idiopathic myelofibrosis
|
|
gptkbp:discoveredBy
|
Andersson et al.
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:EC_number
|
2.7.10.1
|
|
gptkbp:encodedBy
|
gptkb:PDGFRB_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000113721
|
|
gptkbp:expressedIn
|
fibroblasts
pericytes
vascular smooth muscle cells
|
|
gptkbp:fullName
|
gptkb:Platelet-derived_growth_factor_receptor_beta
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
angiogenesis
cell differentiation regulation
cell proliferation regulation
|
|
gptkbp:gene
|
gptkb:PDGFRB
|
|
gptkbp:GO_term
|
GO:0005008
|
|
gptkbp:HGNC_ID
|
8804
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDGFRβ
|
|
gptkbp:inhibitedBy
|
gptkb:sorafenib
gptkb:imatinib
gptkb:pazopanib
gptkb:sunitinib
|
|
gptkbp:interactsWith
|
gptkb:PLCγ
gptkb:Src_family_kinases
SH2 domain-containing proteins
|
|
gptkbp:ligand
|
gptkb:PDGF-AB
gptkb:PDGF-BB
PDGF-DD
|
|
gptkbp:locatedOnChromosome
|
5q32
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
180 kDa
|
|
gptkbp:mutationAssociatedWith
|
associated with familial infantile myofibromatosis
associated with myeloproliferative neoplasms
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Pdgfrb
rat Pdgfrb
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:PDB
|
3MJG
|
|
gptkbp:phosphorylates
|
autophosphorylation upon ligand binding
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:structure
|
single-pass type I membrane protein
|
|
gptkbp:subcellularLocation
|
gptkb:plasma_membrane
|
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gptkbp:UniProtID
|
gptkb:P09619
|
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gptkbp:bfsParent
|
gptkb:PDGFRα
|
|
gptkbp:bfsLayer
|
6
|