|
gptkbp:instanceOf
|
gptkb:protein
white blood cell
lymphocyte
|
|
gptkbp:activatedBy
|
gptkb:antigen-MHC_complex
gptkb:interleukin-2
antigen-presenting cell
|
|
gptkbp:alternativeName
|
T_cell
T_cell_receptor
cell_adhesion_molecule
cell_surface_glycoprotein
membrane_receptor
transmembrane_receptor
|
|
gptkbp:associatedWith
|
gptkb:CD3_complex
|
|
gptkbp:binds
|
gptkb:peptide-MHC_complex
|
|
gptkbp:canBe
|
gptkb:CAR-T_therapy
|
|
gptkbp:canBeCulturedIn
|
gptkb:research_institute
|
|
gptkbp:canBeDeficientIn
|
immunodeficiency
|
|
gptkbp:canBeDepletedBy
|
chemotherapy
|
|
gptkbp:canBeOveractiveIn
|
gptkb:allergy
|
|
gptkbp:canBeTransplantedIn
|
bone marrow transplant
|
|
gptkbp:cause
|
autoimmune disease
|
|
gptkbp:component
|
gptkb:adaptive_immune_system
|
|
gptkbp:composedOf
|
alpha chain
beta chain
delta chain
gamma chain
|
|
gptkbp:database
|
gptkb:Gene_Ontology:GO:0042101
gptkb:UniProt:P01848
|
|
gptkbp:developedBy
|
hematopoietic stem cell
|
|
gptkbp:discoveredBy
|
gptkb:James_P._Allison
gptkb:Jacques_Miller
|
|
gptkbp:discoveredIn
|
1960s
|
|
gptkbp:doesNotRecognize
|
native antigens
|
|
gptkbp:encodedBy
|
TCR genes
|
|
gptkbp:expressedIn
|
cell surface receptor
T lymphocytes
|
|
gptkbp:foundIn
|
gptkb:T_cells
blood
lymphatic system
|
|
gptkbp:function
|
antigen recognition
regulate immune response
destroy infected cells
help B cells produce antibodies
|
|
gptkbp:geneRearrangement
|
VDJ recombination
|
|
gptkbp:hasRole
|
gptkb:adaptive_immune_system
|
|
gptkbp:infects
|
gptkb:HIV
|
|
gptkbp:involvedIn
|
gptkb:graft-versus-host_disease
immunotherapy
autoimmunity
cell-mediated immunity
|
|
gptkbp:launched
|
T cell activation
|
|
gptkbp:lifespan
|
weeks to years
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:marking
|
gptkb:CD3
gptkb:CD4
gptkb:CD8
|
|
gptkbp:maturation
|
gptkb:thymus
|
|
gptkbp:measures
|
flow cytometry
|
|
gptkbp:molecularWeight
|
~90 kDa
|
|
gptkbp:mutationAssociatedWith
|
immunodeficiency
|
|
gptkbp:proliferatesIn
|
lymph nodes
|
|
gptkbp:recognizedBy
|
antigen peptides
|
|
gptkbp:relatedTo
|
gptkb:B_cell
gptkb:dendritic_cell
B cell receptor
natural killer cell
|
|
gptkbp:requires
|
antigen presentation
MHC molecules
|
|
gptkbp:response
|
immune response
|
|
gptkbp:role
|
immune response
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
other vertebrates
|
|
gptkbp:structure
|
heterodimer
|
|
gptkbp:subspecies
|
gptkb:gamma_delta_T_cell
cytotoxic T cell
helper T cell
memory T cell
regulatory T cell
|
|
gptkbp:subunit
|
constant region
cytoplasmic tail
transmembrane region
variable region
|
|
gptkbp:suppressedBy
|
immunosuppressive drugs
|
|
gptkbp:surfaceProtein
|
gptkb:CD28
gptkb:CD7
gptkb:CD45RA
gptkb:CD45RO
CD2
CD5
|
|
gptkbp:target
|
gptkb:CAR-T_therapy
gptkb:TCR-engineered_T_cell_therapy
immunotherapy
|
|
gptkbp:type
|
gptkb:alpha-beta_TCR
gptkb:gamma-delta_TCR
|
|
gptkbp:bfsParent
|
gptkb:G_protein-coupled_receptor
gptkb:immune_response
gptkb:Killer_T_Cell
|
|
gptkbp:bfsLayer
|
5
|