|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:beta-type_platelet-derived_growth_factor_receptor
gptkb:CD140b
|
|
gptkbp:associatedWith
|
gptkb:idiopathic_basal_ganglia_calcification
gptkb:chronic_myelomonocytic_leukemia
gptkb:dermatofibrosarcoma_protuberans
gptkb:infantile_myofibromatosis
myeloproliferative neoplasms
|
|
gptkbp:biologicalProcess
|
ATP binding
protein tyrosine kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
Andersson et al.
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:encodedBy
|
gptkb:PDGFRB_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000113721
|
|
gptkbp:fullName
|
gptkb:Platelet-derived_growth_factor_receptor_beta
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
angiogenesis
cell differentiation regulation
cell proliferation regulation
|
|
gptkbp:gene
|
gptkb:PDGFRB
|
|
gptkbp:HGNC_ID
|
HGNC:8804
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDGFRB (human)
|
|
gptkbp:interactsWith
|
gptkb:PIK3R1
gptkb:PTPN11
gptkb:PDGFD
gptkb:SRC
gptkb:GRB2
gptkb:CRK
gptkb:PDGFA
gptkb:PDGFB
gptkb:SH2B2
gptkb:STAT3
gptkb:NCK1
PLC gamma 1
|
|
gptkbp:length
|
1106 amino acids
|
|
gptkbp:ligand
|
gptkb:PDGF-AB
gptkb:PDGF-BB
PDGF-DD
|
|
gptkbp:locatedOnChromosome
|
5q32
|
|
gptkbp:molecularWeight
|
123 kDa
|
|
gptkbp:mutationAssociatedWith
|
drug resistance
oncogenic transformation
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Ras_signaling_pathway
|
|
gptkbp:PDB
|
3MJG
5GRN
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:RefSeq
|
NM_002609
|
|
gptkbp:target
|
gptkb:sorafenib
gptkb:imatinib
gptkb:pazopanib
gptkb:regorafenib
gptkb:sunitinib
gptkb:crenolanib
|
|
gptkbp:UniProtID
|
gptkb:P09619
|
|
gptkbp:bfsParent
|
gptkb:Pdgfrb
|
|
gptkbp:bfsLayer
|
7
|