Platelet-derived growth factor receptor beta

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:receptor_tyrosine_kinase gptkb:protein
gptkbp:alternativeName	gptkb:PDGFRB gptkb:CD140b gptkb:PDGFR-beta
gptkbp:associatedWith	gptkb:idiopathic_basal_ganglia_calcification gptkb:chronic_myelomonocytic_leukemia gptkb:infantile_myofibromatosis
gptkbp:biologicalProcess	receptor tyrosine kinase activity
gptkbp:cellularComponent	gptkb:plasma_membrane
gptkbp:discoveredBy	1980s
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000113721
gptkbp:expressedIn	fibroblasts pericytes vascular smooth muscle cells
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	cell differentiation cell proliferation angiogenesis cell growth regulation
gptkbp:gene	gptkb:PDGFRB
gptkbp:HGNC_ID	8804
https://www.w3.org/2000/01/rdf-schema#label	Platelet-derived growth factor receptor beta
gptkbp:interactsWith	gptkb:PIK3R1 gptkb:SRC gptkb:GRB2 gptkb:STAT3 SH2 domain-containing proteins
gptkbp:length	1106
gptkbp:ligand	gptkb:platelet-derived_growth_factor
gptkbp:locatedOnChromosome	gptkb:chromosome_5 5q32
gptkbp:molecularWeight	123 kDa
gptkbp:mutationAssociatedWith	familial infantile myofibromatosis primary familial brain calcification
gptkbp:OMIM	173410
gptkbp:pathway	gptkb:MAPK_signaling_pathway gptkb:PI3K-Akt_signaling_pathway
gptkbp:PDB	3MJG
gptkbp:phosphorylates	tyrosine residues
gptkbp:RefSeq	NM_002609
gptkbp:targetOfDrug	gptkb:sorafenib gptkb:imatinib gptkb:pazopanib gptkb:regorafenib gptkb:sunitinib
gptkbp:UniProtID	gptkb:P09619
gptkbp:bfsParent	gptkb:PDGFRβ gptkb:CD140b gptkb:PDGFR-beta
gptkbp:bfsLayer	7