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gptkbp:instanceOf
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gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CD140b
gptkb:JTK12
gptkb:PDGFR-beta
|
|
gptkbp:biologicalProcess
|
signal transduction
wound healing
transmembrane receptor protein tyrosine kinase activity
ATP binding
regulation of cell growth
regulation of cell migration
protein tyrosine kinase activity
|
|
gptkbp:discoveredBy
|
Andersson et al.
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000113721
5159
|
|
gptkbp:expressedIn
|
fibroblasts
pericytes
vascular smooth muscle cells
|
|
gptkbp:fullName
|
gptkb:platelet-derived_growth_factor_receptor_beta
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
binds platelet-derived growth factor
|
|
gptkbp:HGNC_ID
|
8804
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDGFRB
|
|
gptkbp:inhibitedBy
|
gptkb:sorafenib
gptkb:imatinib
gptkb:pazopanib
gptkb:regorafenib
gptkb:sunitinib
|
|
gptkbp:interactsWith
|
gptkb:PIK3R1
gptkb:PTPN11
gptkb:SRC
gptkb:GRB2
gptkb:PDGFA
gptkb:PDGFB
gptkb:SH2B2
gptkb:STAT3
|
|
gptkbp:involvedIn
|
cell differentiation
cell proliferation
embryonic development
angiogenesis
|
|
gptkbp:locatedOnChromosome
|
5
5q32
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:mutationAssociatedWith
|
gptkb:chronic_myelomonocytic_leukemia
gptkb:dermatofibrosarcoma_protuberans
gptkb:infantile_myofibromatosis
myeloproliferative neoplasms
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Pdgfrb
|
|
gptkbp:UniProtID
|
gptkb:P09619
|
|
gptkbp:bfsParent
|
gptkb:chromosome_5
|
|
gptkbp:bfsLayer
|
5
|