|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CD140a
gptkb:PDGFR-2
gptkb:PDGFR2
gptkb:alpha-type_platelet-derived_growth_factor_receptor
gptkb:PDGFR-alpha
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:gastrointestinal_stromal_tumor
gptkb:acute_myeloid_leukemia
gptkb:glioblastoma
hypereosinophilic syndrome
|
|
gptkbp:biologicalProcess
|
embryonic development
signal transduction
cell growth
ATP binding
protein kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:clinicalTrialPhase
|
companion diagnostic for GIST
|
|
gptkbp:discoveredBy
|
Yarden Y et al.
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:encodes
|
gptkb:PDGFRA_protein
|
|
gptkbp:Entrez_Gene_ID
|
5156
ENSG00000134853
|
|
gptkbp:expressedIn
|
fibroblasts
astrocytes
mesenchymal cells
|
|
gptkbp:fullName
|
gptkb:platelet-derived_growth_factor_receptor_alpha
|
|
gptkbp:function
|
cell differentiation regulation
cell proliferation regulation
receptor tyrosine kinase activity
|
|
gptkbp:gene
|
gptkb:PDGFRA
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:8803
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDGFRA
|
|
gptkbp:interactsWith
|
gptkb:PDGFC
gptkb:PDGFD
gptkb:PDGFA
gptkb:PDGFB
|
|
gptkbp:length
|
1089 amino acids
60,000 bp (approximate)
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4
4q12
|
|
gptkbp:molecularWeight
|
122 kDa
|
|
gptkbp:mutationAssociatedWith
|
oncogenic activation
D842V
V561D
Y849C
exon 12 deletion
exon 18 mutation
|
|
gptkbp:numberOfExons
|
23
|
|
gptkbp:OMIM
|
173490
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Pdgfra
|
|
gptkbp:orthologInZebrafish
|
pdgfra
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Ras_signaling_pathway
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
ubiquitination
|
|
gptkbp:proteinFamily
|
receptor tyrosine kinase family
|
|
gptkbp:regulates
|
dimerization
autophosphorylation
ligand binding
|
|
gptkbp:subcellularLocation
|
gptkb:endosome
gptkb:cell_membrane
gptkb:cytoplasm
|
|
gptkbp:targetOfDrug
|
gptkb:imatinib
gptkb:regorafenib
gptkb:sunitinib
|
|
gptkbp:transmembraneDomains
|
yes
|
|
gptkbp:UniProtID
|
P16234
|
|
gptkbp:bfsParent
|
gptkb:PDGFR
gptkb:chromosome_4
gptkb:PDGFRα
gptkb:KEGG:_hsa04014
|
|
gptkbp:bfsLayer
|
6
|