platelet-derived growth factor receptor alpha

URI: https://gptkb.org/entity/platelet-derived_growth_factor_receptor_alpha
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:receptor_tyrosine_kinase
gptkb:protein
gptkbp:alternativeName gptkb:CD140a
gptkb:PDGFRα
gptkbp:associatedWith gptkb:gastrointestinal_stromal_tumor
gptkb:glioblastoma
hypereosinophilic syndrome
gptkbp:biologicalProcess cell differentiation
cell proliferation
embryonic development
receptor activity
protein tyrosine kinase activity
gptkbp:cellularComponent gptkb:plasma_membrane
gptkbp:discoveredBy 1980s
gptkbp:Entrez_Gene_ID ENSG00000134853
gptkbp:expressedIn fibroblasts
astrocytes
mesenchymal cells
gptkbp:extracellular_domain immunoglobulin-like domains
gptkbp:forms_dimer_with gptkb:platelet-derived_growth_factor_receptor_beta
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:gene gptkb:PDGFRA
gptkbp:HGNC_ID 8803
https://www.w3.org/2000/01/rdf-schema#label platelet-derived growth factor receptor alpha
gptkbp:intracellular_domain tyrosine kinase domain
gptkbp:involves gptkb:JAK-STAT_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkbp:ligand gptkb:platelet-derived_growth_factor_(PDGF)
gptkbp:locatedOnChromosome gptkb:chromosome_4
4q12
gptkbp:mutationAssociatedWith gain-of-function
loss-of-function
oncogenic transformation
gptkbp:OMIM 173490
gptkbp:orthologInMouse gptkb:Pdgfra
gptkbp:phosphorylates tyrosine residues
gptkbp:RefSeq NM_006206
gptkbp:regulates phosphorylation
ligand binding
gptkbp:significance therapeutic target
cancer biomarker
gptkbp:structure single-pass type I membrane protein
gptkbp:targetOfDrug gptkb:imatinib
gptkb:sunitinib
gptkbp:UniProtID P16234
gptkbp:bfsParent gptkb:PDGFRA
gptkb:PDGF_receptor_alpha
gptkbp:bfsLayer 7