gastrointestinal stromal tumor

URI: https://gptkb.org/entity/gastrointestinal_stromal_tumor
GPTKB entity
Statements (56)
Predicate Object
gptkbp:instanceOf gptkb:disease
brain tumor
gptkbp:affects digestive system
gptkbp:benign_potential yes
gptkbp:cell_of_origin gptkb:interstitial_cells_of_Cajal
gptkbp:diagnostic_method imaging
biopsy
immunohistochemistry
gptkbp:firstDescribed 1983
gptkbp:frequency rare
gptkbp:gene gptkb:PDGFRA
gptkb:KIT
gptkbp:hasOrphanetID ORPHA595
gptkbp:hasWikipediaPage https://en.wikipedia.org/wiki/Gastrointestinal_stromal_tumor
https://www.w3.org/2000/01/rdf-schema#label gastrointestinal stromal tumor
gptkbp:ICD-10_code C49.A
gptkbp:incidence 10-20 per million per year
gptkbp:location gptkb:small_intestine
gastrointestinal tract
stomach
gptkbp:malignant_potential yes
gptkbp:marking gptkb:CD117
gptkb:DOG1
gptkbp:MeSH_ID D054549
gptkbp:metastasis_site liver
peritoneum
gptkbp:notable_drug_resistance imatinib (in some cases)
gptkbp:OMIM 606764
gptkbp:prognosis variable
gptkbp:rare_location colon
esophagus
rectum
gptkbp:relatedTo gptkb:Carney-Stratakis_syndrome
gptkb:Carney_triad
gptkbp:riskFactor gptkb:neurofibromatosis_type_1
age over 50
gptkbp:specialty oncology
gastroenterology
gptkbp:symptom nausea
vomiting
abdominal pain
gastrointestinal bleeding
weight loss
gptkbp:treatment gptkb:imatinib
gptkb:regorafenib
gptkb:sunitinib
gptkb:ripretinib
surgery
gptkbp:UMLS_CUI C0206686
gptkbp:bfsParent gptkb:CHEMBL958
gptkb:PDGFR
gptkb:imatinib_(Gleevec)
gptkb:Gleevec
gptkb:Gastric_cancer
gptkb:PDGFRα
gptkbp:bfsLayer 6