|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:gastrointestinal_stromal_tumor
gptkb:idiopathic_hypereosinophilic_syndrome
gptkb:glioblastoma
|
|
gptkbp:biologicalProcess
|
cell differentiation
cell proliferation
embryonic development
wound healing
protein tyrosine kinase activity
transmembrane receptor activity
|
|
gptkbp:dimerization
|
ligand-induced
|
|
gptkbp:encodedBy
|
gptkb:PDGFRA_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000134853
|
|
gptkbp:fullName
|
gptkb:Platelet-derived_growth_factor_receptor_alpha
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
binds platelet-derived growth factors
|
|
gptkbp:gene
|
gptkb:PDGFRA
|
|
gptkbp:HGNC_ID
|
8803
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDGFR-alpha
|
|
gptkbp:inhibitedBy
|
gptkb:dasatinib
gptkb:imatinib
gptkb:sunitinib
gptkb:crenolanib
|
|
gptkbp:interactsWith
|
gptkb:PDGF-A
gptkb:PDGF-B
gptkb:PDGF-C
gptkb:PDGF-D
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4q12
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:mutationAssociatedWith
|
drug resistance
oncogenic activation
|
|
gptkbp:OMIM
|
173490
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:PDB
|
5K5X
|
|
gptkbp:phosphorylates
|
autophosphorylation upon activation
|
|
gptkbp:RefSeq
|
NP_006197
|
|
gptkbp:structure
|
transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
|
|
gptkbp:tissue_specificity
|
fibroblasts
embryonic tissues
mesenchymal cells
smooth muscle cells
|
|
gptkbp:UniProtID
|
P16234
|
|
gptkbp:bfsParent
|
gptkb:PDGFR
|
|
gptkbp:bfsLayer
|
6
|