hypereosinophilic syndrome

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:disease syndrome
gptkbp:affects	gptkb:skin gptkb:nervous_system lungs cardiac system hematologic system
gptkbp:alternativeName	gptkb:idiopathic_hypereosinophilic_syndrome gptkb:HES
gptkbp:associatedWith	gptkb:FIP1L1-PDGFRA_fusion_gene
gptkbp:cause	heart failure pulmonary fibrosis peripheral neuropathy thromboembolism organ damage
gptkbp:causedBy	unknown genetic disorder lymphocytic variant myeloproliferative disorder
gptkbp:firstDescribed	1968
gptkbp:hasDiagnosticCriteria	persistent eosinophilia >1500/μL for more than 6 months exclusion of other causes of eosinophilia
gptkbp:hasOrphanetID	gptkb:ORPHA:324
gptkbp:ICD-10_code	gptkb:D72.1
gptkbp:MeSH_ID	gptkb:D006967
gptkbp:OMIM	606800
gptkbp:prevalence	rare
gptkbp:prognosis	variable
gptkbp:riskFactor	middle age male gender
gptkbp:subspecies	gptkb:lymphocytic_HES gptkb:myeloproliferative_HES
gptkbp:symptom	fever fatigue weight loss cough shortness of breath skin rash neurological symptoms eosinophilia cardiac involvement
gptkbp:treatment	gptkb:interferon-alpha gptkb:hydroxyurea gptkb:imatinib corticosteroids monoclonal antibodies
gptkbp:bfsParent	gptkb:PDGFR gptkb:imatinib_(Gleevec) gptkb:Gleevec gptkb:Eosinophil-associated_syndrome
gptkbp:bfsLayer	6