|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CD140a
gptkb:alpha-type_platelet-derived_growth_factor_receptor
|
|
gptkbp:associatedWith
|
gptkb:glioblastoma
hypereosinophilic syndrome
gastrointestinal stromal tumors
chronic myeloproliferative disorders
|
|
gptkbp:biologicalProcess
|
cell differentiation
cell proliferation
embryonic development
transmembrane receptor protein tyrosine kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
Andersson et al.
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:domain
|
protein kinase domain
immunoglobulin-like domain
|
|
gptkbp:encodedBy
|
gptkb:PDGFRA_gene
|
|
gptkbp:fullName
|
gptkb:platelet-derived_growth_factor_receptor_alpha
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
binds platelet-derived growth factors
|
|
gptkbp:GO_term
|
GO:0005007
|
|
gptkbp:HGNC_ID
|
HGNC:8803
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDGFRA protein
|
|
gptkbp:interactsWith
|
gptkb:PDGFC
gptkb:PDGFD
gptkb:PDGFA
gptkb:PDGFB
|
|
gptkbp:locatedOnChromosome
|
4q12
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
~124 kDa
|
|
gptkbp:mutationAssociatedWith
|
oncogenic activation
D842V
V561D
Y849C
|
|
gptkbp:orthologIn
|
mouse PDGFRA
rat PDGFRA
|
|
gptkbp:PDB
|
5K5X
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:subunit
|
homodimer
heterodimer with PDGFRB
|
|
gptkbp:target
|
gptkb:avapritinib
gptkb:imatinib
gptkb:crenolanib
|
|
gptkbp:type
|
gptkb:MAPK_pathway
gptkb:PI3K-AKT_pathway
gptkb:PLCĪ³_pathway
|
|
gptkbp:UniProtID
|
P16234
ENSP00000257290
|
|
gptkbp:bfsParent
|
gptkb:PDGFRA
gptkb:PDGFRA_gene
|
|
gptkbp:bfsLayer
|
7
|