|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:FK506-binding_protein_12-rapamycin-associated_protein_1
gptkb:FRAP
RAFT1
RAPT1
|
|
gptkbp:associatedWith
|
gptkb:tuberous_sclerosis
gptkb:cancer
gptkb:type_2_diabetes
neurodegenerative diseases
|
|
gptkbp:complexity
|
gptkb:mTORC1
gptkb:mTORC2
|
|
gptkbp:discoveredBy
|
gptkb:David_M._Sabatini
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:fullName
|
gptkb:mechanistic_target_of_rapamycin
|
|
gptkbp:function
|
regulation of cell proliferation
regulation of cell survival
regulation of autophagy
regulation of cell growth
regulation of cell motility
regulation of protein synthesis
serine/threonine kinase
|
|
gptkbp:gene
|
gptkb:MTOR
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
mTOR protein
|
|
gptkbp:inhibitedBy
|
gptkb:everolimus
gptkb:rapamycin
gptkb:sirolimus
gptkb:temsirolimus
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p36.2
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~289 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
gptkb:mTOR_signaling_pathway
gptkb:PI3K-Akt-mTOR_pathway
|
|
gptkbp:phosphorylates
|
gptkb:4EBP1
gptkb:S6K1
|
|
gptkbp:UniProtID
|
gptkb:P42345
|
|
gptkbp:bfsParent
|
gptkb:MTOR
gptkb:mTOR_signaling_pathway
gptkb:CCI-779
|
|
gptkbp:bfsLayer
|
7
|