mechanistic target of rapamycin

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:alsoKnownAs	gptkb:mTOR gptkb:FRAP1
gptkbp:associatedWith	gptkb:cancer gptkb:diabetes aging neurodegenerative diseases
gptkbp:biologicalProcess	serine/threonine kinase activity
gptkbp:component	gptkb:mTORC1 gptkb:mTORC2
gptkbp:discoveredBy	gptkb:David_Sabatini
gptkbp:discoveredIn	1994
gptkbp:encodedBy	gptkb:MTOR_gene
gptkbp:function	regulation of cell proliferation regulation of cell survival regulation of autophagy regulation of cell growth regulation of cell motility regulation of protein synthesis
gptkbp:inhibitedBy	gptkb:everolimus gptkb:rapamycin gptkb:sirolimus gptkb:temsirolimus
gptkbp:locatedIn	gptkb:nucleus gptkb:cytoplasm
gptkbp:locatedOnChromosome	gptkb:1p36.2
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:pathway	gptkb:PI3K-Akt-mTOR_pathway insulin signaling pathway autophagy regulation pathway
gptkbp:regulates	gptkb:4E-BP1 gptkb:Akt gptkb:HIF-1α gptkb:PKCα gptkb:SGK1 gptkb:ULK1 gptkb:immune_response gptkb:ribosomal_protein_S6_kinase angiogenesis cell cycle progression glucose metabolism autophagy lipid biosynthesis protein translation
gptkbp:UniProtID	gptkb:P42345
gptkbp:bfsParent	gptkb:mTOR
gptkbp:bfsLayer	6
https://www.w3.org/2000/01/rdf-schema#label	mechanistic target of rapamycin