mechanistic target of rapamycin

GPTKB entity

Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alsoKnownAs gptkb:mTOR
gptkb:FRAP1
gptkbp:associatedWith gptkb:cancer
gptkb:diabetes
aging
neurodegenerative diseases
gptkbp:biologicalProcess serine/threonine kinase activity
gptkbp:component gptkb:mTORC1
gptkb:mTORC2
gptkbp:discoveredBy gptkb:David_Sabatini
gptkbp:discoveredIn 1994
gptkbp:encodedBy gptkb:MTOR_gene
gptkbp:function regulation of cell proliferation
regulation of cell survival
regulation of autophagy
regulation of cell growth
regulation of cell motility
regulation of protein synthesis
https://www.w3.org/2000/01/rdf-schema#label mechanistic target of rapamycin
gptkbp:inhibitedBy gptkb:everolimus
gptkb:rapamycin
gptkb:sirolimus
gptkb:temsirolimus
gptkbp:locatedIn gptkb:nucleus
gptkb:cytoplasm
gptkbp:locatedOnChromosome gptkb:1p36.2
gptkbp:organism gptkb:Homo_sapiens
gptkbp:pathway gptkb:PI3K-Akt-mTOR_pathway
insulin signaling pathway
autophagy regulation pathway
gptkbp:regulates gptkb:4E-BP1
gptkb:Akt
gptkb:HIF-1α
gptkb:PKCα
gptkb:SGK1
gptkb:ULK1
gptkb:ribosomal_protein_S6_kinase
angiogenesis
cell cycle progression
glucose metabolism
immune response
autophagy
lipid biosynthesis
protein translation
gptkbp:UniProtID gptkb:P42345
gptkbp:bfsParent gptkb:mTOR
gptkbp:bfsLayer 6