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mechanistic target of rapamycin
URI:
https://gptkb.org/entity/mechanistic_target_of_rapamycin
GPTKB entity
Statements (49)
Predicate
Object
gptkbp:instanceOf
gptkb:protein
gptkb:enzyme
gptkbp:alsoKnownAs
gptkb:mTOR
gptkb:FRAP1
gptkbp:associatedWith
gptkb:cancer
gptkb:diabetes
aging
neurodegenerative diseases
gptkbp:biologicalProcess
serine/threonine kinase activity
gptkbp:component
gptkb:mTORC1
gptkb:mTORC2
gptkbp:discoveredBy
gptkb:David_Sabatini
gptkbp:discoveredIn
1994
gptkbp:encodedBy
gptkb:MTOR_gene
gptkbp:function
regulation of cell proliferation
regulation of cell survival
regulation of autophagy
regulation of cell growth
regulation of cell motility
regulation of protein synthesis
https://www.w3.org/2000/01/rdf-schema#label
mechanistic target of rapamycin
gptkbp:inhibitedBy
gptkb:everolimus
gptkb:rapamycin
gptkb:sirolimus
gptkb:temsirolimus
gptkbp:locatedIn
gptkb:nucleus
gptkb:cytoplasm
gptkbp:locatedOnChromosome
gptkb:1p36.2
gptkbp:organism
gptkb:Homo_sapiens
gptkbp:pathway
gptkb:PI3K-Akt-mTOR_pathway
insulin signaling pathway
autophagy regulation pathway
gptkbp:regulates
gptkb:4E-BP1
gptkb:Akt
gptkb:HIF-1α
gptkb:PKCα
gptkb:SGK1
gptkb:ULK1
gptkb:ribosomal_protein_S6_kinase
angiogenesis
cell cycle progression
glucose metabolism
immune response
autophagy
lipid biosynthesis
protein translation
gptkbp:UniProtID
gptkb:P42345
gptkbp:bfsParent
gptkb:mTOR
gptkbp:bfsLayer
6