|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
activated by stress signals
|
|
gptkbp:alternativeName
|
SAPKγ
JNK3a
MAP kinase 10
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
epilepsy
stroke
|
|
gptkbp:discoveredBy
|
Kyriakis et al.
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:encodedBy
|
MAPK10 gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000107643
5602
|
|
gptkbp:enzymeClassification
|
gptkb:EC_2.7.11.24
|
|
gptkbp:family
|
gptkb:Mitogen-activated_protein_kinase
|
|
gptkbp:fullName
|
c-Jun N-terminal kinase 3
|
|
gptkbp:function
|
involved in neuronal apoptosis
phosphorylates c-Jun and other transcription factors
|
|
gptkbp:gene
|
gptkb:MAPK10
|
|
gptkbp:GO
|
gptkb:GO:0004707
|
|
gptkbp:HGNC_ID
|
6882
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
JNK3
|
|
gptkbp:inhibitedBy
|
gptkb:SP600125
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4q21
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~54 kDa
|
|
gptkbp:OMIM
|
602896
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Jnk3
rat Jnk3
|
|
gptkbp:pathway
|
gptkb:JNK_signaling_pathway
gptkb:MAPK_signaling_pathway
|
|
gptkbp:PDB
|
gptkb:4QTD
3E7O
|
|
gptkbp:phosphorylates
|
Thr221
Tyr223
|
|
gptkbp:product
|
serine/threonine kinase
|
|
gptkbp:RefSeq
|
NM_002753
|
|
gptkbp:regulates
|
activated by dual phosphorylation
regulated by upstream kinases MKK4 and MKK7
|
|
gptkbp:significance
|
implicated in neurodegenerative diseases
implicated in ischemic brain injury
|
|
gptkbp:substrate
|
gptkb:ATF2
gptkb:Elk-1
gptkb:c-Jun
|
|
gptkbp:tissue_specificity
|
primarily expressed in brain, heart, and testis
|
|
gptkbp:UniProtID
|
gptkb:P53779
|
|
gptkbp:bfsParent
|
gptkb:JNK_proteins
gptkb:MAPK10
gptkb:MKK4
gptkb:MKK7
|
|
gptkbp:bfsLayer
|
7
|