|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:MKK7
gptkb:JNKK2
gptkb:PRKMK7
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:biologicalProcess
|
apoptotic process
protein serine/threonine kinase activity
cellular response to stress
|
|
gptkbp:discoveredBy
|
gptkb:Dérijard_B_et_al.
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodes
|
gptkb:MAP_kinase_kinase_7_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000105379
5609
|
|
gptkbp:expressedIn
|
brain
heart
liver
|
|
gptkbp:fullName
|
gptkb:Mitogen-activated_protein_kinase_kinase_7
|
|
gptkbp:function
|
involved in stress-activated protein kinase signaling pathway
activates JNK MAP kinases
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOID
|
gptkb:GO:0004708
|
|
gptkbp:HGNC_ID
|
6845
|
|
gptkbp:interactsWith
|
gptkb:TAK1
gptkb:MAP3K1
gptkb:JIP1
gptkb:MAP3K7
|
|
gptkbp:length
|
419 amino acids
|
|
gptkbp:locatedOnChromosome
|
19
|
|
gptkbp:location
|
gptkb:19p13.3
|
|
gptkbp:molecularWeight
|
44 kDa
|
|
gptkbp:OMIM
|
603166
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Map2k7
gptkb:rat_Map2k7
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:JNK_cascade
|
|
gptkbp:phosphorylates
|
gptkb:MAPK10
gptkb:MAPK9
gptkb:MAPK8
|
|
gptkbp:regulates
|
activated by phosphorylation
inhibited by dual-specificity phosphatases
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:O14733
|
|
gptkbp:bfsParent
|
gptkb:MAPK10
gptkb:MAPK9
gptkb:MKK7
gptkb:c-Jun_N-terminal_kinase_pathway
gptkb:MAP3K1
gptkb:MAPK8
gptkb:MAP_kinase_kinase_(MAP2K)
gptkb:R-HSA-5673005
gptkb:DLK
gptkb:Mitogen-activated_protein_kinase_8
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAP2K7
|