Statements (26)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:chemical_compound
kinase inhibitor |
| gptkbp:application |
study of JNK signaling pathways
|
| gptkbp:CASNumber |
1410888-41-9
|
| gptkbp:criteria |
selective for JNKs over other kinases
|
| gptkbp:discoveredBy |
Jiahuai Han lab
|
| gptkbp:discoveredIn |
2012
|
| gptkbp:hasMolecularFormula |
C18H16N4O3S
|
| https://www.w3.org/2000/01/rdf-schema#label |
JNK-IN-8
|
| gptkbp:inhibitedBy |
gptkb:JNK1
gptkb:JNK2 gptkb:JNK3 |
| gptkbp:irreversible |
yes
|
| gptkbp:IUPACName |
(2R,3S)-N-(1,3-benzodioxol-5-yl)-2-(4-(4-methylpiperazin-1-yl)anilino)-3-thiophen-2-ylpropanamide
|
| gptkbp:mechanismOfAction |
irreversible inhibitor
|
| gptkbp:publishedIn |
gptkb:Nature_Chemical_Biology
|
| gptkbp:synonym |
JNK inhibitor VIII
|
| gptkbp:target |
gptkb:MAPK10
gptkb:MAPK9 gptkb:MAPK8 |
| gptkbp:usedIn |
biological research
|
| gptkbp:bfsParent |
gptkb:c-Jun_N-terminal_kinase_pathway
gptkb:MAPK/JNK_pathway gptkb:MAPK8 gptkb:Mitogen-activated_protein_kinase_8 |
| gptkbp:bfsLayer |
7
|