|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:HPK1
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune diseases
|
|
gptkbp:biologicalProcess
|
cell differentiation
signal transduction
apoptotic process
protein kinase activity
|
|
gptkbp:discoveredBy
|
Y. Hu et al.
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:domain
|
gptkb:CNH_domain
protein kinase domain
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000107902
11184
|
|
gptkbp:expressedIn
|
gptkb:T-cells
lymphoid tissues
|
|
gptkbp:fullName
|
gptkb:Mitogen-activated_protein_kinase_kinase_kinase_kinase_1
|
|
gptkbp:function
|
serine/threonine-protein kinase activity
regulation of immune response
involved in T-cell receptor signaling pathway
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOID
|
gptkb:GO:0004707
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:6842
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAP4K1
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:MAP3K1
gptkb:TRAF2
|
|
gptkbp:locatedOnChromosome
|
19
|
|
gptkbp:location
|
gptkb:19q13.12
|
|
gptkbp:modulatedBy
|
immune cell signaling
|
|
gptkbp:OMIM
|
604522
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:partOf
|
gptkb:MAPK_signaling_pathway
|
|
gptkbp:PDB
|
gptkb:2F3V
|
|
gptkbp:phosphorylates
|
gptkb:MAP3K1
gptkb:Ser171
JNK pathway components
Thr165
|
|
gptkbp:regulates
|
gptkb:JNK_signaling_pathway
gptkb:B-cell_receptor_signaling_pathway
gptkb:NF-kappaB_signaling_pathway
T-cell activation
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
membrane-associated
|
|
gptkbp:UniProtID
|
Q92918
|
|
gptkbp:bfsParent
|
gptkb:HPK
|
|
gptkbp:bfsLayer
|
6
|