|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:anti-apoptotic_members
|
gptkb:Bcl-2
gptkb:Bcl-xL
gptkb:Bcl-w
gptkb:Mcl-1
A1
|
|
gptkbp:discoveredBy
|
late 1980s
|
|
gptkbp:domain
|
gptkb:BH1
gptkb:BH4
BH3
BH2
|
|
gptkbp:function
|
regulation of apoptosis
|
|
gptkbp:hasMember
|
gptkb:Bcl-2
gptkb:Bcl-xL
gptkb:Puma
gptkb:Bid
gptkb:Bax
gptkb:Bcl-B
gptkb:Bcl-G
gptkb:Bcl-Rambo
gptkb:Bcl-w
gptkb:Bcl2L10
gptkb:Bik
gptkb:Bim
gptkb:Bmf
gptkb:Mcl-1
gptkb:Noxa
gptkb:Bak
Bad
A1
Hrk
|
|
gptkbp:involves
|
cell survival
cell death
intrinsic apoptosis pathway
|
|
gptkbp:location
|
gptkb:endoplasmic_reticulum
cytosol
mitochondrial outer membrane
|
|
gptkbp:mechanismOfAction
|
regulate mitochondrial outer membrane permeabilization
control cytochrome c release
interact with caspases
|
|
gptkbp:namedAfter
|
gptkb:B-cell_lymphoma_2_(Bcl-2)_protein
|
|
gptkbp:pro-apoptotic_BH3-only_members
|
gptkb:Puma
gptkb:Bid
gptkb:Bik
gptkb:Bim
gptkb:Bmf
gptkb:Noxa
Bad
Hrk
|
|
gptkbp:pro-apoptotic_members
|
gptkb:Bax
gptkb:Bok
gptkb:Bak
|
|
gptkbp:proteinFamily
|
BCL2 gene family
|
|
gptkbp:regulates
|
cell fate
apoptotic signaling
mitochondrial integrity
|
|
gptkbp:role
|
gptkb:cancer
neurodegenerative diseases
autoimmune diseases
|
|
gptkbp:subclassOf
|
anti-apoptotic proteins
pro-apoptotic proteins
|
|
gptkbp:target
|
gptkb:BH3_mimetics
anticancer drugs
|
|
gptkbp:bfsParent
|
gptkb:JNK_pathway
gptkb:KCA-872
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Bcl-2 family proteins
|