|
gptkbp:instanceOf
|
biological pathway
|
|
gptkbp:activatedBy
|
gptkb:G_protein-coupled_receptors
gptkb:receptor_tyrosine_kinases
cytokines
growth factors
|
|
gptkbp:alsoKnownAs
|
gptkb:MAPK/ERK_pathway
|
|
gptkbp:downstreamOf
|
transcription factor activation
gene expression changes
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
neurodegenerative diseases
developmental disorders
|
|
gptkbp:firstDescribed
|
1990s
|
|
gptkbp:foundIn
|
eukaryotic cells
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ERK signaling pathway
|
|
gptkbp:includes
|
gptkb:ERK1/2
gptkb:MEK1/2
gptkb:RAF_kinase
|
|
gptkbp:involves
|
extracellular signal-regulated kinases (ERKs)
mitogen-activated protein kinases (MAPKs)
|
|
gptkbp:launched
|
gptkb:RAS_protein
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
cell cycle progression
cell migration
|
|
gptkbp:relatedTo
|
gptkb:JNK_pathway
gptkb:p38_MAPK_pathway
|
|
gptkbp:studiedIn
|
cancer research
molecular biology
|
|
gptkbp:target
|
gptkb:MEK_inhibitors
gptkb:RAF_inhibitors
cancer therapeutics
|
|
gptkbp:bfsParent
|
gptkb:DUSP22
gptkb:AP1
|
|
gptkbp:bfsLayer
|
7
|