|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:HRAS1
gptkb:v-Ha-ras_Harvey_rat_sarcoma_viral_oncogene_homolog
gptkb:C-H-Ras
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodedBy
|
gptkb:HRAS_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000174775
3265
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:Harvey_rat_sarcoma_viral_oncogene_homolog
|
|
gptkbp:function
|
guanine nucleotide exchange factor
signal transduction
|
|
gptkbp:HGNC_ID
|
5173
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HRas
|
|
gptkbp:interactsWith
|
gptkb:GAPs_(GTPase-activating_proteins)
gptkb:PIK3CA
gptkb:RAF1
gptkb:SOS1
|
|
gptkbp:length
|
189
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p15.5
chromosome 11
|
|
gptkbp:location
|
gptkb:Golgi_apparatus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:memberOf
|
gptkb:Ras_subfamily
gptkb:small_GTPase_superfamily
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Costello_syndrome
gptkb:head_and_neck_squamous_cell_carcinoma
oncogenic
bladder cancer
gain-of-function
|
|
gptkbp:OMIM
|
190020
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Hras1
|
|
gptkbp:PDB
|
gptkb:5P21
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:roleInPathway
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
gptkb:Ras_signaling_pathway
|
|
gptkbp:significance
|
tumor suppressor
cancer biomarker
|
|
gptkbp:UniProtID
|
gptkb:P01112
|
|
gptkbp:bfsParent
|
gptkb:M-Ras_proteins
gptkb:PF00057
gptkb:p21_H-Ras
gptkb:small_GTPase_family
gptkb:PF00071
gptkb:GTPase_proteins
gptkb:mouse_Hras
|
|
gptkbp:bfsLayer
|
7
|