|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
gptkb:Cardiofaciocutaneous_syndrome
gptkb:Costello_syndrome
gptkb:Noonan_syndrome
|
|
gptkbp:component
|
gptkb:plasma_membrane
|
|
gptkbp:contains
|
gptkb:MRAS
gptkb:RRAS
gptkb:RRAS2
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
RRAS3
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:form
|
GTP-bound
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
GTP binding
GTPase activity
|
|
gptkbp:GOProcess
|
signal transduction
|
|
gptkbp:inactiveForm
|
GDP-bound
|
|
gptkbp:interactsWith
|
gptkb:PI3K
gptkb:RAF_kinase
gptkb:RalGDS
|
|
gptkbp:involvedIn
|
cell signal transduction
|
|
gptkbp:locale
|
gptkb:plasma_membrane
endomembranes
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_11_(HRAS)
gptkb:chromosome_12_(KRAS)
gptkb:chromosome_1_(NRAS)
|
|
gptkbp:molecularWeight
|
~21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
|
|
gptkbp:namedAfter
|
gptkb:rat_sarcoma_virus
|
|
gptkbp:orthologIn
|
gptkb:yeast
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
|
|
gptkbp:partOf
|
gptkb:Ras_superfamily
|
|
gptkbp:PDB
|
gptkb:5P21
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
carboxymethylation
|
|
gptkbp:regulates
|
gptkb:GDIs_(guanine_nucleotide_dissociation_inhibitors)
gptkb:GAPs_(GTPase-activating_proteins)
gptkb:GEFs_(guanine_nucleotide_exchange_factors)
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:structure
|
G domain
|
|
gptkbp:UniProtFamilyID
|
gptkb:PF00071
|
|
gptkbp:bfsParent
|
gptkb:HRas_protein
gptkb:HRas_proto-oncogene,_GTPase
gptkb:RIT1_gene
gptkb:Rit1
gptkb:H-Ras
gptkb:N-Ras
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Ras subfamily
|