|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:alias
|
gptkb:c-Ha-ras
gptkb:Harvey_rat_sarcoma_viral_oncogene_homolog
gptkb:HRas
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Costello_syndrome
bladder cancer
gastric cancer
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodedBy
|
gptkb:HRAS_gene
|
|
gptkbp:Entrez_Gene_ID
|
3265
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
guanine nucleotide exchange factor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p21 H-Ras
|
|
gptkbp:interactsWith
|
gptkb:RASA1
gptkb:PI3K
gptkb:GRB2
gptkb:RAF1
gptkb:SOS1
|
|
gptkbp:involvedIn
|
signal transduction
|
|
gptkbp:locale
|
gptkb:plasma_membrane
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p15.5
|
|
gptkbp:memberOf
|
gptkb:Ras_protein_family
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:G12V
gptkb:G13D
gptkb:Q61L
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:5P21
gptkb:1QRA
3K8Y
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:regulates
|
gptkb:GAPs_(GTPase-activating_proteins)
gptkb:GEFs_(guanine_nucleotide_exchange_factors)
|
|
gptkbp:requires
|
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:structure
|
contains G-domain
|
|
gptkbp:UniProtID
|
gptkb:P01112
|
|
gptkbp:bfsParent
|
gptkb:Hras1
|
|
gptkbp:bfsLayer
|
6
|