|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:alsoKnownAs
|
gptkb:HRAS
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:decommissioned
|
GTPase-activating proteins (GAPs)
|
|
gptkbp:determines
|
X-ray crystallography
NMR spectroscopy
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:domain
|
gptkb:GTP-binding_domain
CAAX motif
|
|
gptkbp:encodedBy
|
gptkb:HRAS_gene
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
guanine nucleotide exchange factor
|
|
gptkbp:hasIsoform
|
p21-H-Ras
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
C-H-Ras
|
|
gptkbp:involvedIn
|
regulation of cell differentiation
cell signal transduction
regulation of cell growth
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_11p15.5
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:memberOf
|
gptkb:Ras_family
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:G12V
gptkb:Q61L
G13R
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:5P21
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:regulates
|
gptkb:Ral-GDS_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:relatedTo
|
gptkb:K-Ras
gptkb:N-Ras
|
|
gptkbp:sequence
|
P01112 (UniProt)
|
|
gptkbp:significance
|
gptkb:cancer
gptkb:Costello_syndrome
gptkb:head_and_neck_squamous_cell_carcinoma
bladder cancer
|
|
gptkbp:subcellularLocation
|
inner surface of plasma membrane
|
|
gptkbp:UniProtID
|
gptkb:P01112
|
|
gptkbp:bfsParent
|
gptkb:HRas
|
|
gptkbp:bfsLayer
|
8
|