GAPs (GTPase-activating proteins)
GPTKB entity
Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:binds |
GTPases
|
| gptkbp:category |
cell biology
molecular biology signal transduction proteins |
| gptkbp:example |
gptkb:ArfGAP
gptkb:RasGAP gptkb:RhoGAP |
| gptkbp:foundIn |
prokaryotes
eukaryotes |
| gptkbp:function |
stimulate GTPase activity of G proteins
|
| https://www.w3.org/2000/01/rdf-schema#label |
GAPs (GTPase-activating proteins)
|
| gptkbp:involvedIn |
cell differentiation
vesicle trafficking cell growth cytoskeletal organization oncogenesis |
| gptkbp:mechanismOfAction |
increase hydrolysis of GTP to GDP
|
| gptkbp:mutationAssociatedWith |
can lead to cancer
|
| gptkbp:opposedBy |
gptkb:GEFs_(guanine_nucleotide_exchange_factors)
|
| gptkbp:regulates |
gptkb:Ras_proteins
signal transduction cell signaling Arf proteins GTP-binding proteins Rab proteins Ran proteins Rho proteins |
| gptkbp:bfsParent |
gptkb:HRAS
|
| gptkbp:bfsLayer |
5
|