|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activeState
|
GTP-bound
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:catalyzes
|
GTP hydrolysis
|
|
gptkbp:contains
|
gptkb:Ras_proteins
Arf proteins
Rab proteins
Ran proteins
Rho proteins
heterotrimeric G proteins
|
|
gptkbp:discoveredIn
|
1970s
|
|
gptkbp:EC_number
|
3.6.5.-
|
|
gptkbp:example
|
gptkb:Ran
gptkb:Arf1
gptkb:Rab5
gptkb:RhoA
gptkb:Cdc42
gptkb:HRas
gptkb:KRas
gptkb:NRas
gptkb:Gαq
Gαi
Gαs
|
|
gptkbp:foundIn
|
all domains of life
|
|
gptkbp:function
|
hydrolyze GTP to GDP
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GTPase proteins
|
|
gptkbp:inactiveState
|
GDP-bound
|
|
gptkbp:involvedIn
|
cell differentiation
signal transduction
cell division
immune response
membrane trafficking
|
|
gptkbp:mechanismOfAction
|
molecular switch
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
developmental disorders
neurological diseases
|
|
gptkbp:regulates
|
gptkb:GDIs_(guanine_nucleotide_dissociation_inhibitors)
gptkb:GAPs_(GTPase-activating_proteins)
gptkb:GEFs_(guanine_nucleotide_exchange_factors)
vesicle trafficking
cell growth
cell signaling
protein synthesis
cytoskeleton organization
nuclear transport
|
|
gptkbp:structure
|
G domain (GTP-binding domain)
|
|
gptkbp:subclassOf
|
enzymes
|
|
gptkbp:bfsParent
|
gptkb:GTPase_superfamily
gptkb:GTP-binding_domain
|
|
gptkbp:bfsLayer
|
6
|