|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Bek
gptkb:KGFR
gptkb:CD332
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:domain
|
immunoglobulin-like domain
tyrosine kinase domain
|
|
gptkbp:encodedBy
|
gptkb:FGFR2_gene
|
|
gptkbp:Entrez_Gene_ID
|
2263
|
|
gptkbp:expressedIn
|
epithelial cells
mesenchymal cells
|
|
gptkbp:fullName
|
gptkb:Fibroblast_growth_factor_receptor_2
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
binds fibroblast growth factors
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:3689
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FGFR2 protein
|
|
gptkbp:interactsWith
|
gptkb:PIK3R1
gptkb:PLCγ
gptkb:SHC1
gptkb:FGF1
gptkb:FGF2
gptkb:FGF7
gptkb:GRB2
gptkb:FGF10
|
|
gptkbp:involvedIn
|
cell differentiation
cell proliferation
embryonic development
wound healing
angiogenesis
|
|
gptkbp:locatedOnChromosome
|
gptkb:10q26
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
~120 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Endometrial_cancer
gptkb:Apert_syndrome
gptkb:Beare-Stevenson_cutis_gyrata_syndrome
gptkb:Crouzon_syndrome
gptkb:Jackson-Weiss_syndrome
gptkb:Pfeiffer_syndrome
Breast cancer
|
|
gptkbp:OMIM
|
176943
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
gptkb:1EV2
gptkb:2PSQ
gptkb:2PVF
2FDB
|
|
gptkbp:phosphorylates
|
autophosphorylation upon ligand binding
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
ubiquitination
|
|
gptkbp:signalTransductionPathway
|
gptkb:MAPK_pathway
gptkb:PI3K-AKT_pathway
gptkb:PLCγ_pathway
gptkb:STAT_pathway
|
|
gptkbp:UniProtID
|
gptkb:P21802
|
|
gptkbp:bfsParent
|
gptkb:FGFR2
|
|
gptkbp:bfsLayer
|
6
|