|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:FGFR2
|
|
gptkbp:cellSurfaceMarker
|
yes
|
|
gptkbp:downstreamOf
|
gptkb:MAPK_pathway
gptkb:PI3K-AKT_pathway
gptkb:PLCĪ³_pathway
gptkb:STAT_pathway
|
|
gptkbp:encodedBy
|
gptkb:FGFR2_gene
|
|
gptkbp:expressedIn
|
epithelial cells
mesenchymal cells
|
|
gptkbp:fullName
|
gptkb:Fibroblast_growth_factor_receptor_2
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
binds fibroblast growth factors
|
|
gptkbp:gene
|
gptkb:FGFR2
|
|
gptkbp:hasIsoform
|
gptkb:FGFR2b
gptkb:FGFR2c
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:3689
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD332
|
|
gptkbp:involvedIn
|
cell differentiation
wound healing
angiogenesis
cell growth
|
|
gptkbp:locatedOnChromosome
|
gptkb:10q26
|
|
gptkbp:molecularWeight
|
~120 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Endometrial_cancer
gptkb:Apert_syndrome
gptkb:Beare-Stevenson_cutis_gyrata_syndrome
gptkb:Crouzon_syndrome
gptkb:Jackson-Weiss_syndrome
gptkb:Pfeiffer_syndrome
Breast cancer
|
|
gptkbp:OMIM
|
176943
|
|
gptkbp:PDB
|
gptkb:1EV2
|
|
gptkbp:phosphorylates
|
activates downstream signaling pathways
|
|
gptkbp:structure
|
transmembrane domain
intracellular tyrosine kinase domain
extracellular immunoglobulin-like domains
|
|
gptkbp:targetOfDrug
|
gptkb:AZD4547
gptkb:PRN1371
gptkb:BGJ398
gptkb:Debio_1347
gptkb:Dovitinib
gptkb:Erdafitinib
gptkb:Futibatinib
gptkb:Infigratinib
gptkb:Lucitanib
gptkb:Pemigatinib
gptkb:Ponatinib
gptkb:Rogaratinib
gptkb:TAS-120
FGFR inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P21802
|
|
gptkbp:bfsParent
|
gptkb:FGFR2
|
|
gptkbp:bfsLayer
|
6
|