Mitogen-activated protein kinase 3

URI: https://gptkb.org/entity/Mitogen-activated_protein_kinase_3
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alsoKnownAs gptkb:ERK1
gptkb:Extracellular_signal-regulated_kinase_1
gptkbp:biologicalProcess cell proliferation
differentiation
MAPK cascade
protein serine/threonine kinase activity
transcription regulation
gptkbp:cellularComponent gptkb:nucleus
gptkb:cytoplasm
gptkbp:enzymeCommissionNumber 2.7.11.24
gptkbp:expressedIn many tissues
gptkbp:gene gptkb:MAPK3
gptkbp:gene_id_(NCBI) 5595
https://www.w3.org/2000/01/rdf-schema#label Mitogen-activated protein kinase 3
gptkbp:interactsWith gptkb:MAPK1
gptkb:ELK1
gptkb:JUN
gptkb:FOS
gptkb:MYC
gptkb:RSK1
gptkbp:involved_in_disease gptkb:cancer
gptkb:Noonan_syndrome
neurodevelopmental disorders
gptkbp:length 379
gptkbp:locatedIn gptkb:Homo_sapiens
gptkbp:locatedOnChromosome gptkb:16p11.2
gptkbp:molecularWeight 43 kDa
gptkbp:orthologInMouse gptkb:Mapk3
gptkbp:part_of_pathway gptkb:MAPK/ERK_pathway
gptkbp:pdb_id 2ZOQ
4QTB
gptkbp:phosphorylates gptkb:MAP2K1
gptkb:MAP2K2
gptkbp:product gptkb:MAPK3
gptkbp:refseq_mRNA NM_002745.4
gptkbp:refseq_protein NP_002736.3
gptkbp:regulates apoptosis
cell differentiation
gene expression
cell migration
cell cycle
gptkbp:substrate gptkb:MAP2K1
gptkb:MAP2K2
gptkbp:UniProtID gptkb:P27361
gptkbp:bfsParent gptkb:ERK1
gptkb:MAPK3
gptkb:MAPK3_gene
gptkbp:bfsLayer 7