|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activity
|
kinase activity
|
|
gptkbp:alsoKnownAs
|
gptkb:ERK1
gptkb:MAPK3
|
|
gptkbp:encodedBy
|
gptkb:MAPK3_gene
|
|
gptkbp:function
|
signal transduction
regulation of meiosis
regulation of mitosis
regulation of postmitotic functions in differentiated cells
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p44-ERK
|
|
gptkbp:interactsWith
|
gptkb:MAP2K1
gptkb:ELK1
gptkb:MNK1
gptkb:RSK
gptkb:c-Myc
gptkb:MAP2K2
gptkb:DUSP5
gptkb:DUSP6
gptkb:c-Fos
PLA2G4A
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_pathway
apoptosis
cell differentiation
cell proliferation
cell survival
developmental processes
transcription regulation
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
chromosome 16p11.2
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
gptkb:ERK_subfamily
|
|
gptkbp:molecularWeight
|
44 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
2ZOQ
4QTB
|
|
gptkbp:phosphorylates
|
gptkb:MEK1
gptkb:MEK2
threonine 202
tyrosine 204
|
|
gptkbp:significance
|
gptkb:cancer
neurological disorders
developmental syndromes
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:structure
|
serine/threonine kinase
|
|
gptkbp:UniProtID
|
gptkb:P27361
|
|
gptkbp:bfsParent
|
gptkb:ERK1
|
|
gptkbp:bfsLayer
|
7
|