Extracellular signal-regulated kinase 1

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:activatedBy	gptkb:MEK1 gptkb:MEK2
gptkbp:alsoKnownAs	gptkb:ERK1
gptkbp:discoveredIn	1991
gptkbp:encodedBy	gptkb:MAPK3_gene
gptkbp:expressedIn	various tissues
gptkbp:function	signal transduction serine/threonine kinase
gptkbp:gene	gptkb:MAPK3
gptkbp:GO_term	gptkb:GO:0004674 GO:0000165
gptkbp:inhibitedBy	gptkb:PD98059 gptkb:U0126
gptkbp:involvedIn	gptkb:MAPK/ERK_pathway cell differentiation cell proliferation cell survival
gptkbp:locatedOnChromosome	gptkb:16p11.2
gptkbp:memberOf	mitogen-activated protein kinase family
gptkbp:molecularWeight	44 kDa
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Rattus_norvegicus
gptkbp:PDB	2ZOQ
gptkbp:phosphorylates	transcription factors cytoskeletal proteins threonine 202 tyrosine 204
gptkbp:regulates	apoptosis gene expression cell cycle progression
gptkbp:relatedTo	gptkb:Extracellular_signal-regulated_kinase_2
gptkbp:reviewedBy	gptkb:GeneCards gptkb:NCBI_Gene gptkb:UniProt
gptkbp:significance	gptkb:cancer developmental disorders
gptkbp:structure	contains protein kinase domain
gptkbp:subcellularLocation	gptkb:nucleus gptkb:cytoplasm
gptkbp:UniProtID	gptkb:P27361
gptkbp:bfsParent	gptkb:ERK1 gptkb:MAPK3_gene
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Extracellular signal-regulated kinase 1