Extracellular signal-regulated kinase 1

URI: https://gptkb.org/entity/Extracellular_signal-regulated_kinase_1
GPTKB entity
Statements (46)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:activatedBy gptkb:MEK1
gptkb:MEK2
gptkbp:alsoKnownAs gptkb:ERK1
gptkbp:discoveredIn 1991
gptkbp:encodedBy gptkb:MAPK3_gene
gptkbp:expressedIn various tissues
gptkbp:function signal transduction
serine/threonine kinase
gptkbp:gene gptkb:MAPK3
gptkbp:GO_term gptkb:GO:0004674
GO:0000165
https://www.w3.org/2000/01/rdf-schema#label Extracellular signal-regulated kinase 1
gptkbp:inhibitedBy gptkb:PD98059
gptkb:U0126
gptkbp:involvedIn gptkb:MAPK/ERK_pathway
cell differentiation
cell proliferation
cell survival
gptkbp:locatedOnChromosome gptkb:16p11.2
gptkbp:memberOf mitogen-activated protein kinase family
gptkbp:molecularWeight 44 kDa
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:PDB 2ZOQ
gptkbp:phosphorylates transcription factors
cytoskeletal proteins
threonine 202
tyrosine 204
gptkbp:regulates apoptosis
gene expression
cell cycle progression
gptkbp:relatedTo gptkb:Extracellular_signal-regulated_kinase_2
gptkbp:reviewedBy gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:UniProt
gptkbp:significance gptkb:cancer
developmental disorders
gptkbp:structure contains protein kinase domain
gptkbp:subcellularLocation gptkb:nucleus
gptkb:cytoplasm
gptkbp:UniProtID gptkb:P27361
gptkbp:bfsParent gptkb:ERK1
gptkb:MAPK3_gene
gptkbp:bfsLayer 7