|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:ERK1
gptkb:Mitogen-activated_protein_kinase_3
|
|
gptkbp:associatedWith
|
gptkb:cancer
developmental disorders
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodedBy
|
gptkb:MAPK3_gene
|
|
gptkbp:enzymeClassification
|
serine/threonine kinase
|
|
gptkbp:expressedIn
|
brain
heart
liver
many tissues
|
|
gptkbp:function
|
signal transduction
regulation of cell proliferation
regulation of transcription
regulation of differentiation
|
|
gptkbp:gene
|
gptkb:MAPK3
|
|
gptkbp:GO_term
|
gptkb:GO:0004674
GO:0000165
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAP kinase 3
|
|
gptkbp:inhibitedBy
|
gptkb:PD98059
gptkb:U0126
gptkb:FR180204
|
|
gptkbp:interactsWith
|
gptkb:ELK1
gptkb:c-Myc
gptkb:DUSP6
gptkb:p53
gptkb:RSK1
gptkb:c-Fos
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_pathway
|
|
gptkbp:length
|
379 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:16p11.2
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
gptkb:ERK_subfamily
|
|
gptkbp:molecularWeight
|
44 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
2ZOQ
4QTB
|
|
gptkbp:phosphorylates
|
gptkb:MEK1
gptkb:MEK2
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
transcription factors
cell cycle proteins
|
|
gptkbp:UniProtID
|
gptkb:P27361
|
|
gptkbp:bfsParent
|
gptkb:ERK1
|
|
gptkbp:bfsLayer
|
7
|