mitogen-activated protein kinase
GPTKB entity
Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abbreviation |
gptkb:MAPK
|
| gptkbp:activatedBy |
gptkb:MAP_kinase_kinase_(MAP2K)
|
| gptkbp:contains |
serine/threonine kinase domain
|
| gptkbp:firstDescribed |
1990s
|
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
phosphorylates target proteins
|
| gptkbp:hasIsoform |
gptkb:ERK1
gptkb:ERK2 gptkb:JNK1 gptkb:JNK2 gptkb:p38_MAPK |
| https://www.w3.org/2000/01/rdf-schema#label |
mitogen-activated protein kinase
|
| gptkbp:involvedIn |
apoptosis
cell differentiation cell proliferation cell signaling stress response |
| gptkbp:memberOf |
gptkb:MAPK/ERK_pathway
gptkb:JNK_pathway gptkb:p38_MAPK_pathway |
| gptkbp:proteinFamily |
gptkb:MAPK_family
|
| gptkbp:regulates |
cell survival
gene expression cell cycle cell death |
| gptkbp:relatedTo |
gptkb:cancer
neurodegenerative diseases inflammation |
| gptkbp:superfamily |
gptkb:protein_kinase_superfamily
|
| gptkbp:target |
pharmaceutical inhibitors
|
| gptkbp:bfsParent |
gptkb:MAPK/ERK_pathway
|
| gptkbp:bfsLayer |
5
|