|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:MEK1
gptkb:MEK2
|
|
gptkbp:alsoKnownAs
|
gptkb:ERK2
gptkb:MAPK1
|
|
gptkbp:discoveredBy
|
Meloche et al.
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:EC_number
|
2.7.11.24
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
serine/threonine kinase
|
|
gptkbp:gene
|
gptkb:MAPK1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p44-MAPK
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_signaling_pathway
apoptosis
cell differentiation
cell proliferation
cell survival
development
cancer progression
transcription regulation
|
|
gptkbp:locatedOnChromosome
|
22q11.22
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
44 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Noonan_syndrome
|
|
gptkbp:OMIM
|
176948
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Mapk1
rat Mapk1
|
|
gptkbp:PDB
|
gptkb:2ERK
1TVO
3SA0
|
|
gptkbp:phosphorylates
|
transcription factors
cytoskeletal proteins
other kinases
threonine 185
tyrosine 187
|
|
gptkbp:regulates
|
activated by dual phosphorylation
inhibited by phosphatases
|
|
gptkbp:structure
|
contains protein kinase domain
|
|
gptkbp:UniProtID
|
gptkb:P28482
|
|
gptkbp:bfsParent
|
gptkb:ERK1
|
|
gptkbp:bfsLayer
|
7
|