|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:MEK1
gptkb:MEK2
|
|
gptkbp:alternativeName
|
gptkb:MAPK3
gptkb:p44_MAPK
|
|
gptkbp:discoveredBy
|
Meloche S et al.
|
|
gptkbp:EC_number
|
2.7.11.24
|
|
gptkbp:enzymeClassification
|
serine/threonine kinase
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
gptkb:Extracellular_signal-regulated_kinase_1
|
|
gptkbp:function
|
signal transduction
|
|
gptkbp:gene
|
gptkb:MAPK3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ERK-1
|
|
gptkbp:involvedIn
|
apoptosis
cell differentiation
cell proliferation
cell survival
development
|
|
gptkbp:involves
|
gptkb:cancer
neurodegenerative diseases
inflammatory diseases
|
|
gptkbp:locatedOnChromosome
|
gptkb:16p11.2
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
44 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
gptkb:MAPK/ERK_pathway
|
|
gptkbp:phosphorylates
|
transcription factors
threonine 202
tyrosine 204
|
|
gptkbp:regulates
|
gene expression
metabolism
cell cycle
|
|
gptkbp:relatedTo
|
gptkb:MAPK1
gptkb:ERK-2
|
|
gptkbp:target
|
pharmacological inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P27361
|
|
gptkbp:bfsParent
|
gptkb:ERK1
gptkb:MAPK3_gene
|
|
gptkbp:bfsLayer
|
7
|