BRCA1-associated protein complex
GPTKB entity
Statements (67)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:Oncology
gptkb:BRCA1_gene gptkb:hereditary_breast_and_ovarian_cancer_syndrome gptkb:anemia ovarian cancer DNA damage response cellular senescence tumorigenesis cancer risk assessment cancer therapies genetic predisposition to cancer therapeutic targets in cancer genetic testing for cancer risk oncogenic mutations DNA repair syndromes clinical implications in oncology |
| gptkbp:challenges |
increased cancer risk
|
| gptkbp:composed_of |
gptkb:BRCA1_protein
gptkb:BARD1_protein gptkb:BRCA1-BARD1_heterodimer |
| gptkbp:function |
DNA repair
|
| https://www.w3.org/2000/01/rdf-schema#label |
BRCA1-associated protein complex
|
| gptkbp:interacts_with |
gptkb:ATM_kinase
gptkb:H2_AX gptkb:CHEK2 gptkb:ATM_protein gptkb:BRCA2 gptkb:FANCD2 gptkb:MRE11 gptkb:PALB2 gptkb:RAD52 gptkb:PTEN gptkb:p53 gptkb:RAD51 p21 NBS1 Ubc H5 |
| gptkbp:involved_in |
apoptosis regulation
cellular homeostasis cellular stress response chromatin remodeling homologous recombination cellular proliferation chromosomal stability tumor suppression cellular differentiation genomic stability DNA double-strand break repair cellular signaling pathways protein-protein interactions cellular repair mechanisms cellular response to DNA damage telomere maintenance tumor microenvironment interactions cellular repair pathways cellular signaling networks cellular apoptosis pathways protein ubiquitination repair of interstrand cross-links repair of single-strand breaks |
| gptkbp:located_in |
gptkb:Atom
|
| gptkbp:regulates |
cell cycle
gene expression DNA repair pathways |
| gptkbp:bfsParent |
gptkb:BRCA1_gene
|
| gptkbp:bfsLayer |
7
|