Statements (65)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:Oncology
gptkb:anemia gptkb:pancreatic_cancer ovarian cancer fallopian tube cancer male breast cancer peritoneal cancer |
| gptkbp:clinical_trial |
therapeutic target
predictive biomarker |
| gptkbp:discovered_by |
gptkb:1990
|
| gptkbp:diseases |
gptkb:BRCA1-related_breast_cancer
gptkb:BRCA1-related_ovarian_cancer |
| gptkbp:function |
DNA repair
|
| gptkbp:genetic_studies |
can be inherited
can be sporadic increases cancer risk leads to loss of function |
| https://www.w3.org/2000/01/rdf-schema#label |
BRCA1 protein
|
| gptkbp:initiated_by |
cell proliferation
|
| gptkbp:interacts_with |
BRCA2 protein
|
| gptkbp:involved_in |
DNA damage response
cell cycle regulation homologous recombination transcription regulation genomic stability |
| gptkbp:is_expressed_in |
regulated by hormones
|
| gptkbp:knockouts |
gptkb:p53
gptkb:RAD51 |
| gptkbp:located_in |
gptkb:Atom
|
| gptkbp:pathway |
DNA repair pathway
|
| gptkbp:produced_by |
gptkb:BRCA1_gene
|
| gptkbp:promoter |
gptkb:BRCA1
|
| gptkbp:promotes |
apoptosis
|
| gptkbp:research |
gptkb:gene_therapy
gptkb:immunotherapy animal models biomarker discovery clinical trials ethical considerations patient outcomes risk assessment health disparities ongoing studies genetic counseling targeted therapy population studies functional studies pathway analysis epigenetic regulation therapeutic resistance clinical applications drug resistance biological assays molecular mechanisms survivorship studies public health implications screening methods genetic testing guidelines cell line studies |
| gptkbp:type |
tumor suppressor
|
| gptkbp:bfsParent |
gptkb:BRCA1-BARD1_complex
gptkb:BRCA1-RAP80_complex gptkb:BRCA1_gene |
| gptkbp:bfsLayer |
7
|