Statements (81)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:disease
gptkb:anemia genetic disorder blood disorder |
| gptkbp:affects |
hemoglobin
red blood cells |
| gptkbp:alternativeName |
Anemia
hemolytic_anemia thalassemia |
| gptkbp:can_be_acute_or_chronic |
true
|
| gptkbp:can_be_inherited_or_acquired |
true
|
| gptkbp:cause |
gptkb:diabetes_mellitus
autoimmune disorders heart failure splenomegaly medications hereditary conditions toxins infections skeletal abnormalities delayed puberty growth retardation ineffective erythropoiesis reduced hemoglobin production premature destruction of red blood cells |
| gptkbp:causedBy |
mutations in HBB gene
mutations in HBA1 gene mutations in HBA2 gene |
| gptkbp:complication |
gptkb:liver_disease
heart failure heart problems infections gallstones iron overload |
| gptkbp:diagnosedBy |
gptkb:Coombs_test
blood test genetic testing blood tests hemoglobin electrophoresis |
| gptkbp:firstDescribed |
1925
|
| https://www.w3.org/2000/01/rdf-schema#label |
anemia
|
| gptkbp:ICD-10_code |
D56
D55-D59 |
| gptkbp:inheritsFrom |
autosomal recessive inheritance
|
| gptkbp:MeSH_ID |
D013792
|
| gptkbp:namedAfter |
Greek word 'thalassa' meaning 'sea'
|
| gptkbp:OMIM |
141800
|
| gptkbp:prevalence |
common in Mediterranean, Middle Eastern, South Asian, and African populations
|
| gptkbp:prevention |
prenatal screening
genetic counseling |
| gptkbp:riskFactor |
family history
ancestry from Mediterranean, Middle Eastern, South Asian, or African regions |
| gptkbp:subspecies |
gptkb:G6PD_deficiency
gptkb:sickle_cell_anemia gptkb:autoimmune_hemolytic_anemia gptkb:hereditary_spherocytosis gptkb:thalassemia_intermedia gptkb:thalassemia_major gptkb:thalassemia_minor beta thalassemia alpha thalassemia |
| gptkbp:symptom |
gptkb:anemia
fatigue jaundice enlarged spleen shortness of breath pallor pale skin bone deformities delayed growth dark urine |
| gptkbp:treatment |
gptkb:splenectomy
blood transfusion corticosteroids bone marrow transplant immunosuppressive drugs iron chelation therapy |
| gptkbp:bfsParent |
gptkb:Vitamin_E
gptkb:Malaria gptkb:Vitamin_B12 |
| gptkbp:bfsLayer |
4
|