Statements (63)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
homologous recombination
|
| gptkbp:clinical_trial |
gptkb:Oncology
|
| gptkbp:code |
gptkb:RAD52_protein
|
| gptkbp:conservation |
eukaryotes
|
| gptkbp:discovered_by |
gptkb:yeast
|
| gptkbp:function |
DNA repair
|
| gptkbp:genetic_studies |
increased cancer risk
|
| gptkbp:has_function |
strand annealing
|
| gptkbp:has_relationship_with |
gptkb:BRCA1
|
| gptkbp:has_role |
genomic stability
|
| gptkbp:has_variants |
SNPs
|
| https://www.w3.org/2000/01/rdf-schema#label |
RAD52
|
| gptkbp:interacts_with |
gptkb:RAD51
|
| gptkbp:involved_in |
double-strand break repair
|
| gptkbp:is_associated_with |
genetic disorders
chromosomal instability tumorigenesis therapeutic resistance sensitivity to DNA-damaging agents |
| gptkbp:is_essential_for |
cell survival after DNA damage
|
| gptkbp:is_expressed_in |
various tissues
germ cells lymphocytes embryonic stem cells cancerous tissues testicular tissues |
| gptkbp:is_involved_in |
meiosis
cell cycle regulation chromatin remodeling DNA repair mechanisms cellular response to stress genetic recombination telomere maintenance cellular repair processes DNA damage signaling repair of interstrand cross-links repair of oxidative DNA damage repair of UV-induced damage DNA crosslink repair DNA replication stress response DNA strand break repair immunoglobulin class switch recombination repair of DNA double-strand breaks repair of DNA interstrand crosslinks |
| gptkbp:is_linked_to |
gptkb:Oncology
gptkb:neurodegenerative_diseases ovarian cancer breast cancer susceptibility fanconi anemia |
| gptkbp:is_part_of |
DNA damage response
DNA repair pathway DNA repair machinery DNA repair network recombination repair pathway homologous recombination repair complex |
| gptkbp:is_regulated_by |
cell cycle checkpoints
|
| gptkbp:is_studied_in |
cancer research
|
| gptkbp:is_targeted_at |
gptkb:gene_therapy
|
| gptkbp:located_in |
human chromosome 12
|
| gptkbp:orthologs |
gptkb:mouse
|
| gptkbp:bfsParent |
gptkb:RAD51
|
| gptkbp:bfsLayer |
6
|