Statements (118)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
gptkb:immunotherapy
gptkb:Oncology gptkb:triple-negative_breast_cancer gptkb:pancreatic_cancer ovarian cancer clinical trials targeted therapies increased mortality risk tumor characteristics reproductive health issues uterine cancer family planning decisions radiation sensitivity PARP inhibitors fallopian tube cancer male breast cancer psychosocial impact chemotherapy response reduced survival rates risk-reducing strategies |
| gptkbp:availability |
genetic testing
|
| gptkbp:clinical_trial |
gptkb:hereditary_breast_and_ovarian_cancer_syndrome
|
| gptkbp:code |
gptkb:BRCA1_protein
|
| gptkbp:discovered_by |
gptkb:Mary-Claire_King
|
| gptkbp:discovery |
gptkb:Health_Insurance
breast cancer research patient management strategies linkage analysis awareness of hereditary cancer syndromes genetic testing guidelines |
| gptkbp:discovery_year |
gptkb:1990
|
| gptkbp:field_of_study |
gptkb:Genetics
|
| gptkbp:function |
DNA repair
|
| gptkbp:genetic_counseling_importance |
high risk individuals
|
| gptkbp:genetic_studies |
increased cancer risk
frameshift mutation missense mutation germline mutation nonsense mutation familial breast cancer |
| gptkbp:has_role |
repairing double-strand breaks
|
| https://www.w3.org/2000/01/rdf-schema#label |
BRCA1 gene
|
| gptkbp:interacts_with |
BRCA2 protein
|
| gptkbp:involved_in |
homologous recombination
|
| gptkbp:involvement |
DNA double-strand break repair
|
| gptkbp:is_associated_with |
gptkb:Oncology
gptkb:hereditary_breast_and_ovarian_cancer_syndrome gptkb:cervical_cancer neuroendocrine tumors male breast cancer |
| gptkbp:is_essential_for |
genomic stability
|
| gptkbp:is_expressed_in |
brain tissue
breast tissue embryonic stem cells lung tissue ovarian tissue placental tissue testicular tissue |
| gptkbp:is_involved_in |
DNA damage response
apoptosis cellular homeostasis cellular metabolism chromatin remodeling immune response cellular proliferation cellular response to stress cellular senescence chromosomal stability cellular differentiation cellular signaling cellular repair mechanisms telomere maintenance m RNA splicing |
| gptkbp:is_linked_to |
gptkb:disease
gptkb:pancreatic_cancer increased cancer risk endometrial cancer esophageal cancer bladder cancer gastrointestinal cancer fallopian tube cancer |
| gptkbp:is_located_in |
17q21.31
chromosome 17 |
| gptkbp:is_part_of |
gptkb:BRCA1/_BRCA2_repair_complex
gptkb:BRCA1-associated_protein_complex tumor suppressor genes DNA damage checkpoint DNA repair pathways DNA repair complex |
| gptkbp:is_recognized_as |
gptkb:1990
familial breast cancer cases |
| gptkbp:is_recognized_by |
gptkb:Ashkenazi_Jewish_population
|
| gptkbp:is_regulated_by |
estrogen
|
| gptkbp:is_studied_for |
gptkb:gene_therapy
cancer genetics cancer prevention strategies |
| gptkbp:is_studied_in |
clinical trials
population genetics genetic counseling. |
| gptkbp:is_targeted_at |
PARP inhibitors
|
| gptkbp:located_in |
human chromosome 17
|
| gptkbp:nutritional_value |
gptkb:BRCA1_protein
|
| gptkbp:part_of |
BRCA1/ BRCA2 pathway
|
| gptkbp:pathway |
homologous recombination
|
| gptkbp:promoter |
gptkb:BRCA1
|
| gptkbp:regulates |
cell cycle
|
| gptkbp:related_to |
BRCA2 gene
|
| gptkbp:research_focus |
cancer genetics
|
| gptkbp:risk_management |
family history
|
| gptkbp:screenings |
MRI screening
mammography screening |
| gptkbp:seed_dispersal |
tumor suppressor gene
|
| gptkbp:treatment_implication |
preventive mastectomy
preventive oophorectomy |
| gptkbp:bfsParent |
gptkb:hereditary_breast_and_ovarian_cancer
gptkb:BRCA_family |
| gptkbp:bfsLayer |
6
|