Statements (97)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:physicist
gptkb:protein |
| gptkbp:bfsLayer |
5
|
| gptkbp:bfsParent |
gptkb:ATM_protein
|
| gptkbp:application |
gptkb:ATM_kinase
assessing genotoxicity evaluating therapeutic efficacy investigating cancer biology monitoring cellular responses to stress studying DNA repair mechanisms |
| gptkbp:associated_with |
gptkb:healthcare_organization
apoptosis cell cycle regulation genomic instability tumor suppression telomere maintenance |
| gptkbp:clinical_trial |
target for drug development
associated with treatment resistance biomarker for cancer therapy indicator of radiation exposure used in cancer prognosis |
| gptkbp:code |
H2 A histone family member X
|
| gptkbp:discovered_by |
gptkb:Person
gptkb:product gptkb:video_game gptkb:mythological_figure zebrafish researchers studying DNA repair |
| gptkbp:function |
DNA damage response
|
| gptkbp:genetic_diversity |
linked to cancer
|
| gptkbp:has_role |
apoptosis
|
| gptkbp:has_variants |
H2 AX S139 A
|
| https://www.w3.org/2000/01/rdf-schema#label |
H2 AX
|
| gptkbp:intelligence |
other species
|
| gptkbp:interacts_with |
gptkb:ATM_kinase
gptkb:ATM_protein gptkb:ATR_kinase 53 B P1 protein MD C1 protein |
| gptkbp:is_associated_with |
chromosomal instability
tumorigenesis metastasis DNA damage foci |
| gptkbp:is_essential_for |
genomic stability
|
| gptkbp:is_involved_in |
cell cycle regulation
cellular homeostasis homologous recombination cellular senescence non-homologous end joining cellular differentiation cellular repair mechanisms telomere maintenance immune response regulation cellular repair pathways cellular response to ionizing radiation chromatin dynamics double-strand break repair response to UV radiation repair of oxidative damage repair of DNA crosslinks |
| gptkbp:is_linked_to |
gptkb:psychologist
inflammatory responses cancer progression DNA repair pathways aging processes radiation sensitivity |
| gptkbp:is_part_of |
nucleosome structure
DNA repair complexes DNA damage signaling pathways |
| gptkbp:is_represented_in |
gptkb:smartphone
highly conserved various tissues germ cells embryonic stem cells early development cancerous tissues upregulated in response to DNA damage stem cell niches found in all tissues |
| gptkbp:is_studied_in |
genetic disorders
therapeutic interventions cancer research therapeutic targets gene therapy applications biomarker development |
| gptkbp:located_in |
human chromosome 11
|
| gptkbp:location |
gptkb:physicist
|
| gptkbp:metabolism |
occurs at serine 139
|
| gptkbp:modifications |
phosphorylation
|
| gptkbp:origin |
eukaryotes
invertebrates vertebrates |
| gptkbp:part_of |
histone family
|
| gptkbp:promoter |
H2 AX gene
|
| gptkbp:regulates |
p53 protein
gene expression during stress |
| gptkbp:role |
chromatin remodeling
|