|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
DNA double-strand breaks
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:ataxia-telangiectasia
|
|
gptkbp:biologicalProcess
|
serine/threonine protein kinase activity
|
|
gptkbp:discoveredBy
|
gptkb:Yosef_Shiloh
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:EC_number
|
2.7.11.1
|
|
gptkbp:encodedBy
|
gptkb:ATM_gene
|
|
gptkbp:function
|
DNA damage response
cell cycle checkpoint regulation
phosphorylation of target proteins
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ATM kinase
|
|
gptkbp:inhibitedBy
|
gptkb:KU-55933
caffeine
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
gptkb:11q22.3
|
|
gptkbp:mutationAssociatedWith
|
immunodeficiency
neurodegeneration
genomic instability
radiation sensitivity
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_ATM_kinase
gptkb:yeast_Tel1
|
|
gptkbp:phosphorylates
|
gptkb:SMC1
gptkb:53BP1
gptkb:H2AX
gptkb:KAP1
gptkb:MDC1
gptkb:NBS1
gptkb:RAD17
gptkb:ARTEMIS
gptkb:BRCA1
gptkb:p53
gptkb:CHK2
|
|
gptkbp:regulates
|
gptkb:H2AX
gptkb:NBS1
gptkb:BRCA1
gptkb:p53
gptkb:CHK2
apoptosis
DNA repair
cell cycle arrest
|
|
gptkbp:structure
|
gptkb:FATC_domain
gptkb:FAT_domain
gptkb:HEAT_repeats
PI3/PI4-kinase domain
|
|
gptkbp:UniProtID
|
gptkb:Q13315
|
|
gptkbp:bfsParent
|
gptkb:AATF
gptkb:MDM2
|
|
gptkbp:bfsLayer
|
6
|