Statements (64)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:bfsLayer |
6
|
| gptkbp:bfsParent |
gptkb:H2_AX
gptkb:checkpoint_kinase_2 |
| gptkbp:agent |
ionizing radiation
|
| gptkbp:application |
gptkb:H2_AX
gptkb:p53 |
| gptkbp:associated_with |
neurodegeneration
|
| gptkbp:discovered_by |
gptkb:Dr._Andrew_S._Wilkins
|
| gptkbp:established |
gptkb:KU-55933
DNA double-strand breaks apoptosis tumor growth cellular senescence |
| gptkbp:function |
DNA damage response
|
| gptkbp:genetic_diversity |
increased cancer risk
|
| https://www.w3.org/2000/01/rdf-schema#label |
ATM kinase
|
| gptkbp:interacts_with |
MR E11
NB S1 |
| gptkbp:is_involved_in |
cellular homeostasis
cellular metabolism cellular stress response chromatin remodeling immune response cellular proliferation tumor suppression cellular aging cellular differentiation genomic stability cellular signaling pathways cellular communication cellular signaling cellular adaptation telomere maintenance cellular repair pathways cellular repair processes cellular resilience cellular integrity cellular responses to DNA damage cellular responses to infection cellular responses to inflammation cellular responses to injury cellular responses to oxidative stress cellular responses to radiation cellular responses to hypoxia double-strand break repair cellular checkpoints apoptotic signaling cellular recovery cellular responses to environmental stress cellular responses to genotoxic stress cellular responses to metabolic stress cellular responses to nutrient deprivation |
| gptkbp:is_represented_in |
lymphocytes
|
| gptkbp:location |
gptkb:physicist
|
| gptkbp:promoter |
ATM
|
| gptkbp:promotes |
DNA repair mechanisms
|
| gptkbp:regulates |
gene expression
cellular response to stress |
| gptkbp:related_to |
BRC A2
BRC A1 |
| gptkbp:role |
cell cycle regulation
|
| gptkbp:social_responsibility |
gptkb:Ataxia-telangiectasia
|
| gptkbp:type |
serine/threonine kinase
|