Statements (69)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:application |
gptkb:H2_AX
|
| gptkbp:associated_with |
gptkb:ataxia-telangiectasia
|
| gptkbp:code |
gptkb:ATM_gene
|
| gptkbp:function |
DNA damage response
|
| gptkbp:genetic_studies |
gptkb:ataxia-telangiectasia_syndrome
|
| gptkbp:has_role |
cellular repair mechanisms
|
| https://www.w3.org/2000/01/rdf-schema#label |
ATM protein
|
| gptkbp:initiated_by |
gptkb:p53
DNA double-strand breaks cell cycle progression certain cancer therapies |
| gptkbp:interacts_with |
gptkb:BRCA1
gptkb:MRE11 NBS1 |
| gptkbp:involved_in |
double-strand break repair
|
| gptkbp:is_associated_with |
genetic disorders
chronic diseases chromosomal instability cellular dysfunction neurodegeneration therapeutic resistance |
| gptkbp:is_essential_for |
genomic stability
|
| gptkbp:is_expressed_in |
gptkb:embryonic_development
various tissues |
| gptkbp:is_involved_in |
apoptosis
cellular homeostasis cellular metabolism immune response cellular proliferation tumor suppression tumorigenesis cellular aging cellular differentiation cellular signaling pathways cellular communication protein-protein interactions cellular repair mechanisms metabolic regulation telomere maintenance cellular stress responses cellular repair processes cell cycle checkpoint control |
| gptkbp:is_linked_to |
age-related diseases
inflammatory responses metastasis cancer predisposition neurodevelopmental disorders radiation sensitivity |
| gptkbp:is_part_of |
signal transduction pathways
cellular signaling networks DNA damage signaling pathway cancer signaling pathways DNA repair complexes PI3 K-like kinase family |
| gptkbp:is_regulated_by |
ATM kinase activity
|
| gptkbp:is_studied_for |
drug development
therapeutic targets biomarker development |
| gptkbp:is_studied_in |
clinical trials
cancer research |
| gptkbp:is_targeted_at |
small molecule inhibitors
|
| gptkbp:location |
gptkb:Atom
|
| gptkbp:promoter |
ATM
|
| gptkbp:regulates |
cellular response to stress
|
| gptkbp:requires |
homologous recombination
|
| gptkbp:type |
serine/threonine kinase
|
| gptkbp:bfsParent |
gptkb:CHEK2
|
| gptkbp:bfsLayer |
6
|