|
gptkbp:instance_of
|
gptkb:protein
|
|
gptkbp:application
|
target for cancer therapy
|
|
gptkbp:associated_with
|
ataxia-telangiectasia-like disorder
|
|
gptkbp:catalytic_activity
|
exonuclease activity
|
|
gptkbp:cellular_role
|
DNA repair and maintenance
|
|
gptkbp:clinical_trial
|
biomarker for cancer prognosis
|
|
gptkbp:diseases
|
gptkb:Oncology
|
|
gptkbp:function
|
DNA double-strand break repair
|
|
gptkbp:genetic_studies
|
highly conserved across species
increased genomic instability
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MRE11
|
|
gptkbp:initiated_by
|
MRE11 inhibitors
|
|
gptkbp:interacts_with
|
gptkb:RAD50
NBS1
|
|
gptkbp:involved_in
|
DNA damage response
|
|
gptkbp:is_expressed_in
|
various tissues
|
|
gptkbp:localization
|
gptkb:Atom
|
|
gptkbp:nutritional_value
|
MRE11 family
|
|
gptkbp:originated_in
|
gptkb:XLF
gptkb:CHK2
gptkb:H2_AX
gptkb:BRCA2
gptkb:ATR
gptkb:BRCA1
gptkb:DNA-PK
gptkb:FANCA
gptkb:FANCB
gptkb:FANCC
gptkb:FANCD2
gptkb:FANCF
gptkb:FANCL
gptkb:FANCM
gptkb:FANCR
gptkb:Ku70/80
gptkb:MRE11_B
gptkb:TP53
gptkb:RAD51
ATM
RPA
NBS1
FANCG
FANCI
FANCS
FANSH
FANST
|
|
gptkbp:orthologs
|
gptkb:MRE11_B
|
|
gptkbp:part_of
|
gptkb:MRN_complex
|
|
gptkbp:pathway
|
DNA repair pathway
|
|
gptkbp:promoter
|
gptkb:MRE11_A
|
|
gptkbp:role
|
homologous recombination
|
|
gptkbp:structure
|
contains a C-terminal domain
contains an N-terminal domain
|
|
gptkbp:subunit
|
homodimer
|
|
gptkbp:theory
|
Mg2+
|
|
gptkbp:weight
|
approximately 80 k Da
|
|
gptkbp:bfsParent
|
gptkb:BRCA1-RAP80_complex
gptkb:ATM_kinase
gptkb:ATM_protein
|
|
gptkbp:bfsLayer
|
7
|