|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:FANCN
|
|
gptkbp:associatedWith
|
gptkb:Fanconi_anemia_type_N
gptkb:cancer
gptkb:hereditary_breast_cancer
pancreatic cancer
hereditary ovarian cancer
hereditary pancreatic cancer
|
|
gptkbp:biologicalProcess
|
DNA damage response
scaffold for BRCA2
|
|
gptkbp:chromosomeArm
|
gptkb:16p12.2
|
|
gptkbp:clinicalTrialPhase
|
genetic testing for cancer risk
|
|
gptkbp:discoveredBy
|
gptkb:Xiaodong_Wang
|
|
gptkbp:discoveredIn
|
2006
|
|
gptkbp:domain
|
coiled-coil domain
WD40 domain
|
|
gptkbp:encodes
|
gptkb:PALB2_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000083093
79728
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:Partner_and_Localizer_of_BRCA2
|
|
gptkbp:function
|
DNA repair
homologous recombination
|
|
gptkbp:gene
|
gptkb:PALB2
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:26144
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PALB2
|
|
gptkbp:interactsWith
|
gptkb:BRCA1
gptkb:BRCA2
gptkb:RAD51
|
|
gptkbp:length
|
1186 amino acids
|
|
gptkbp:locatedOnChromosome
|
16
|
|
gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Fanconi_anemia
germline
increased cancer risk
somatic
|
|
gptkbp:OMIM
|
610355
|
|
gptkbp:orthologInFruitFly
|
gptkb:CG31950
|
|
gptkbp:orthologInMouse
|
Palb2
|
|
gptkbp:orthologInYeast
|
no direct ortholog
|
|
gptkbp:orthologInZebrafish
|
palb2
|
|
gptkbp:partOf
|
Fanconi anemia pathway
|
|
gptkbp:pathway
|
Fanconi anemia pathway
homologous recombination repair
|
|
gptkbp:regulates
|
DNA double-strand break repair
BRCA2 localization
|
|
gptkbp:UniProtID
|
gptkb:Q86YC2
|
|
gptkbp:bfsParent
|
gptkb:HGNC:1097
gptkb:FANCN
|
|
gptkbp:bfsLayer
|
6
|