Statements (67)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:Oncology
ovarian cancer |
| gptkbp:code |
gptkb:BARD1_gene
|
| gptkbp:contains_domain |
gptkb:BRCT_domain
|
| gptkbp:function |
tumor suppressor
|
| gptkbp:has_relationship_with |
gptkb:RAD51
|
| gptkbp:has_role |
cell cycle regulation
|
| https://www.w3.org/2000/01/rdf-schema#label |
BARD1 protein
|
| gptkbp:interacts_with |
gptkb:BRCA1
|
| gptkbp:involved_in |
DNA repair
|
| gptkbp:is_associated_with |
DNA damage response
tumorigenesis tumor microenvironment cell cycle checkpoints cellular apoptosis pathways chemosensitivity tumorigenic potential |
| gptkbp:is_expressed_in |
gptkb:embryonic_development
various tissues tumor tissues various cancers normal tissues cancer cell lines |
| gptkbp:is_found_in |
human cells
|
| gptkbp:is_involved_in |
apoptosis
cellular homeostasis cellular metabolism chromatin remodeling homologous recombination cellular response to stress cellular differentiation genomic stability protein stability cellular signaling pathways protein-protein interactions cellular repair pathways cellular signaling networks cellular growth regulation cellular repair processes tumor suppression mechanisms |
| gptkbp:is_linked_to |
gptkb:BRCA1-related_cancers
genetic mutations cancer progression cancer susceptibility tumor progression cellular repair mechanisms genetic predisposition to cancer oncogenic processes |
| gptkbp:is_part_of |
gptkb:BRCA1-associated_complex
DNA damage response pathway cellular machinery DNA repair pathways protein complexes nuclear signaling pathways DNA repair machinery nuclear complexes BARD1-BRCA1 complex |
| gptkbp:is_regulated_by |
post-translational modifications
|
| gptkbp:is_studied_for |
cancer therapies
|
| gptkbp:is_studied_in |
cancer research
|
| gptkbp:is_targeted_at |
therapeutic agents
|
| gptkbp:location |
gptkb:Atom
|
| gptkbp:promoter |
gptkb:BARD1
|
| gptkbp:weight |
approximately 80 k Da
|
| gptkbp:bfsParent |
gptkb:BRCA1-BARD1_complex
|
| gptkbp:bfsLayer |
7
|