Statements (57)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:Oncology
ovarian cancer |
| gptkbp:composed_of |
gptkb:BRCA1
gptkb:BARD1 |
| gptkbp:function |
homologous recombination
|
| gptkbp:has_role |
tumor suppression
|
| https://www.w3.org/2000/01/rdf-schema#label |
BRCA1-BARD1 heterodimer
|
| gptkbp:interacts_with |
gptkb:ATM_protein
gptkb:p53 gptkb:RAD51 |
| gptkbp:involved_in |
DNA repair
cellular homeostasis cellular metabolism cellular stress response chromatin remodeling ubiquitination cellular proliferation chromosomal stability tumorigenesis regulation of gene expression cellular aging cellular differentiation genomic stability protein degradation cellular signaling pathways cellular communication cellular signaling protein-protein interactions cellular repair mechanisms cellular adaptation cellular response to DNA damage telomere maintenance cellular repair pathways cellular repair processes cellular apoptosis cellular resilience cellular integrity double-strand break repair response to ionizing radiation homologous recombination repair cellular repair response recruitment of repair factors repair of oxidative DNA damage repair of single-strand breaks response to environmental stress cellular recovery DNA crosslink repair DNA damage checkpoint activation cellular repair activities cellular repair functions maintenance of genomic integrity |
| gptkbp:knockouts |
gptkb:DNA
|
| gptkbp:localization |
gptkb:Atom
|
| gptkbp:regulates |
cell cycle
|
| gptkbp:bfsParent |
gptkb:BRCA1-associated_protein_complex
|
| gptkbp:bfsLayer |
8
|