hereditary breast and ovarian cancer syndrome
GPTKB entity
Statements (48)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Genetics
|
| gptkbp:associated_with |
increased risk of breast cancer
increased risk of ovarian cancer male breast cancer risk pancreatic cancer risk prostate cancer risk |
| gptkbp:caused_by |
gptkb:BRCA1_mutation
gptkb:BRCA2_mutation |
| gptkbp:community_impact |
genetic testing for relatives
increased screening for relatives risk assessment for relatives |
| gptkbp:diagnosis |
genetic testing
|
| gptkbp:discovery_year |
1990s
|
| gptkbp:genetic_studies |
recommended
|
| https://www.w3.org/2000/01/rdf-schema#label |
hereditary breast and ovarian cancer syndrome
|
| gptkbp:inherits_from |
autosomal dominant
|
| gptkbp:is_a_resource_for |
counseling services
support groups online forums |
| gptkbp:legal_issue |
discrimination concerns
insurance coverage for testing |
| gptkbp:notable_case |
gptkb:Maggie_Smith
gptkb:Angelina_Jolie gptkb:Maya_Rudolph gptkb:Sharon_Osbourne gptkb:Christina_Applegate |
| gptkbp:originated_in |
gptkb:BRCA2
gptkb:BRCA1 |
| gptkbp:prevalence |
1 in 400 to 1 in 800 individuals
|
| gptkbp:public_awareness |
gptkb:educational_resources
advocacy groups increased awareness campaigns |
| gptkbp:research_focus |
targeted therapies
risk-reducing strategies BRCA gene therapies |
| gptkbp:risk_factor |
age
gender ethnicity |
| gptkbp:screenings |
MRI scans
annual mammograms pelvic exams |
| gptkbp:symptoms |
family history of breast cancer
family history of ovarian cancer |
| gptkbp:treatment |
surveillance strategies
preventive mastectomy preventive oophorectomy |
| gptkbp:bfsParent |
gptkb:BRCA2
|
| gptkbp:bfsLayer |
5
|