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gptkbp:instanceOf
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gptkb:protein
|
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gptkbp:alsoKnownAs
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gptkb:Retinoblastoma_protein
|
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gptkbp:category
|
tumor suppressor
cell cycle regulator
nuclear protein
|
|
gptkbp:decommissioned
|
gptkb:HPV_E7_protein
gptkb:SV40_large_T_antigen
gptkb:adenovirus_E1A_protein
viral oncoproteins
|
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gptkbp:degradedBy
|
gptkb:proteasome
|
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gptkbp:discoveredBy
|
gptkb:Weinberg_laboratory
|
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gptkbp:encodedBy
|
gptkb:RB1_gene
|
|
gptkbp:firstDescribed
|
1986
|
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gptkbp:foundIn
|
gptkb:Homo_sapiens
|
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gptkbp:function
|
tumor suppressor
regulation of cell cycle
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
pRB protein
|
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gptkbp:inhibitedBy
|
gptkb:E2F_transcription_factors
|
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gptkbp:interactsWith
|
gptkb:Cyclin_D
gptkb:p16INK4a
gptkb:CDK4
gptkb:CDK6
gptkb:DP1
gptkb:E2F1
gptkb:HDAC1
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_13q14
|
|
gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:molecularWeight
|
~110 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:small_cell_lung_carcinoma
gptkb:retinoblastoma
osteosarcoma
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
|
|
gptkbp:phosphorylates
|
gptkb:cyclin-dependent_kinases
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
gptkb:G1/S_transition
apoptosis
cell differentiation
chromatin structure
|
|
gptkbp:requires
|
embryonic development
|
|
gptkbp:structure
|
contains pocket domain
|
|
gptkbp:UniProtID
|
P06400
|
|
gptkbp:bfsParent
|
gptkb:retinoblastoma_pathway
|
|
gptkbp:bfsLayer
|
8
|