Statements (22)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:virus
|
| gptkbp:alternativeSplicing |
multiple isoforms
|
| gptkbp:amendedBy |
host gene expression
|
| gptkbp:encodedBy |
gptkb:adenovirus_E1A_gene
|
| gptkbp:firstDescribed |
1978
|
| gptkbp:foundIn |
gptkb:virus
|
| gptkbp:function |
transcriptional regulator
cell cycle modulator |
| https://www.w3.org/2000/01/rdf-schema#label |
adenovirus E1A protein
|
| gptkbp:interactsWith |
gptkb:Rb_protein
gptkb:CBP gptkb:TFIID gptkb:p300 |
| gptkbp:locale |
gptkb:nucleus
|
| gptkbp:molecularWeight |
~289 amino acids (major isoform)
|
| gptkbp:requires |
adenoviral early gene expression
adenoviral replication |
| gptkbp:role |
oncogenic transformation
apoptosis induction cellular immortalization |
| gptkbp:bfsParent |
gptkb:retinoblastoma-associated_protein
|
| gptkbp:bfsLayer |
7
|